Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy.
This multicenter retrospective study was conducted to evaluate the 1-year treatment outcome of photodynamic therapy (PDT) combined with anti-vascular endothelial growth factor (VEGF) therapy for pachychoroid neovasculopathy (PNV). A total of 42 eyes of 42 patients with treatment-naïve PNV who were t...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248760&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181369036013568 |
|---|---|
| author | Akiko Miki Sentaro Kusuhara Tsuyoshi Otsuji Yu Kawashima Katsuaki Miki Hisanori Imai Makoto Nakamura Akitaka Tsujikawa |
| author_facet | Akiko Miki Sentaro Kusuhara Tsuyoshi Otsuji Yu Kawashima Katsuaki Miki Hisanori Imai Makoto Nakamura Akitaka Tsujikawa |
| author_sort | Akiko Miki |
| collection | DOAJ |
| description | This multicenter retrospective study was conducted to evaluate the 1-year treatment outcome of photodynamic therapy (PDT) combined with anti-vascular endothelial growth factor (VEGF) therapy for pachychoroid neovasculopathy (PNV). A total of 42 eyes of 42 patients with treatment-naïve PNV who were treated with PDT combined with intravitreal injections of an anti-VEGF agent (ranibizumab or aflibercept) for 1 year. All eyes showed exudative and/or hemorrhagic changes that affected the fovea at baseline. After the initial combination therapy, subfoveal choroidal thickness (SCT) and central retinal thickness (CRT) were significantly reduced and were maintained as such for 12 months (P < 0.01 in SCT and CRT). The best-corrected visual acuity (BCVA) (0.19 ± 0.30 at baseline) significantly improved at 3 months (0.15 ± 0.29, P < 0.05) and further improved at 12 months (0.10 ± 0.30, P < 0.01) when compared to that at baseline. After the initial combination therapy, 32 eyes (76.2%) required no additional treatments for 12 months. The mean number of additional PDT and intravitreal injections of anti-VEGF agents was 0.1 ± 0.3 and 0.9 ± 1.9, respectively. Of the 42 eyes included in this study, 22 eyes (52.4%) had polypoidal lesions at baseline. No significant differences in SCT, CRT, or BCVA were observed at any time points between eyes with and without polypoidal lesions. Of 20 eyes without polypoidal lesions, only 1 eye (5.0%) needed additional treatments. PNV, especially without polypoidal lesions, can be treated effectively with PDT combined with anti-VEGF therapy with few sessions. |
| format | Article |
| id | doaj-art-09e5569a83ec4b38abfda68b8d5ac260 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-09e5569a83ec4b38abfda68b8d5ac2602025-08-20T02:17:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024876010.1371/journal.pone.0248760Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy.Akiko MikiSentaro KusuharaTsuyoshi OtsujiYu KawashimaKatsuaki MikiHisanori ImaiMakoto NakamuraAkitaka TsujikawaThis multicenter retrospective study was conducted to evaluate the 1-year treatment outcome of photodynamic therapy (PDT) combined with anti-vascular endothelial growth factor (VEGF) therapy for pachychoroid neovasculopathy (PNV). A total of 42 eyes of 42 patients with treatment-naïve PNV who were treated with PDT combined with intravitreal injections of an anti-VEGF agent (ranibizumab or aflibercept) for 1 year. All eyes showed exudative and/or hemorrhagic changes that affected the fovea at baseline. After the initial combination therapy, subfoveal choroidal thickness (SCT) and central retinal thickness (CRT) were significantly reduced and were maintained as such for 12 months (P < 0.01 in SCT and CRT). The best-corrected visual acuity (BCVA) (0.19 ± 0.30 at baseline) significantly improved at 3 months (0.15 ± 0.29, P < 0.05) and further improved at 12 months (0.10 ± 0.30, P < 0.01) when compared to that at baseline. After the initial combination therapy, 32 eyes (76.2%) required no additional treatments for 12 months. The mean number of additional PDT and intravitreal injections of anti-VEGF agents was 0.1 ± 0.3 and 0.9 ± 1.9, respectively. Of the 42 eyes included in this study, 22 eyes (52.4%) had polypoidal lesions at baseline. No significant differences in SCT, CRT, or BCVA were observed at any time points between eyes with and without polypoidal lesions. Of 20 eyes without polypoidal lesions, only 1 eye (5.0%) needed additional treatments. PNV, especially without polypoidal lesions, can be treated effectively with PDT combined with anti-VEGF therapy with few sessions.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248760&type=printable |
| spellingShingle | Akiko Miki Sentaro Kusuhara Tsuyoshi Otsuji Yu Kawashima Katsuaki Miki Hisanori Imai Makoto Nakamura Akitaka Tsujikawa Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. PLoS ONE |
| title | Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. |
| title_full | Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. |
| title_fullStr | Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. |
| title_full_unstemmed | Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. |
| title_short | Photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy. |
| title_sort | photodynamic therapy combined with anti vascular endothelial growth factor therapy for pachychoroid neovasculopathy |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248760&type=printable |
| work_keys_str_mv | AT akikomiki photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT sentarokusuhara photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT tsuyoshiotsuji photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT yukawashima photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT katsuakimiki photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT hisanoriimai photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT makotonakamura photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy AT akitakatsujikawa photodynamictherapycombinedwithantivascularendothelialgrowthfactortherapyforpachychoroidneovasculopathy |