Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3
Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PP...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/417646 |
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| _version_ | 1850232200624078848 |
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| author | Kenneth K. Wu |
| author_facet | Kenneth K. Wu |
| author_sort | Kenneth K. Wu |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARδ and PPARγ are mediated through enhanced binding of PPAR to the promoter of 14-3-3ε and upregulation of 14-3-3ε expression. We propose that ligand-activated PPARα exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery. |
| format | Article |
| id | doaj-art-09de3bc4aa164fc3a3dffbc709ed199a |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-09de3bc4aa164fc3a3dffbc709ed199a2025-08-20T02:03:16ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/417646417646Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3Kenneth K. Wu0Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, TaiwanPeroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPARδ and PPARγ are mediated through enhanced binding of PPAR to the promoter of 14-3-3ε and upregulation of 14-3-3ε expression. We propose that ligand-activated PPARα exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.http://dx.doi.org/10.1155/2010/417646 |
| spellingShingle | Kenneth K. Wu Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 PPAR Research |
| title | Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 |
| title_full | Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 |
| title_fullStr | Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 |
| title_short | Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 |
| title_sort | peroxisome proliferator activated receptors protect against apoptosis via 14 3 3 |
| url | http://dx.doi.org/10.1155/2010/417646 |
| work_keys_str_mv | AT kennethkwu peroxisomeproliferatoractivatedreceptorsprotectagainstapoptosisvia1433 |