Novel Insights into miRNA in Lung and Heart Inflammatory Diseases
MicroRNAs (miRNAs) are noncoding regulatory sequences that govern posttranscriptional inhibition of genes through binding mainly at regulatory regions. The regulatory mechanism of miRNAs are influenced by complex crosstalk among single nucleotide polymorphisms (SNPs) within miRNA seed region and epi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/259131 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850232200345157632 |
|---|---|
| author | Amit Kishore Jana Borucka Jana Petrkova Martin Petrek |
| author_facet | Amit Kishore Jana Borucka Jana Petrkova Martin Petrek |
| author_sort | Amit Kishore |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are noncoding regulatory sequences that govern posttranscriptional inhibition of genes through binding mainly at regulatory regions. The regulatory mechanism of miRNAs are influenced by complex crosstalk among single nucleotide polymorphisms (SNPs) within miRNA seed region and epigenetic modifications. Circulating miRNAs exhibit potential characteristics as stable biomarker. Functionally, miRNAs are involved in basic regulatory mechanisms of cells including inflammation. Thus, miRNA dysregulation, resulting in aberrant expression of a gene, is suggested to play an important role in disease susceptibility. This review focuses on the role of miRNA as diagnostic marker in pathogenesis of lung inflammatory diseases and in cardiac remodelling events during inflammation. From recent reports, In this context, the information about the models in which miRNAs expression were investigated including types of biological samples, as well as on the methods for miRNA validation and prediction/definition of their gene targets are emphasized in the review. Besides disease pathogenesis, promising role of miRNAs in early disease diagnosis and prognostication is also discussed. However, some miRNAs are also indicated with protective role. Thus, identifications and usage of such potential miRNAs as well as disruption of disease susceptible miRNAs using antagonists, antagomirs, are imperative and may provide a novel therapeutic approach towards combating the disease progression. |
| format | Article |
| id | doaj-art-09dd83e9d6474913bfd0ff44da4bd8f2 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-09dd83e9d6474913bfd0ff44da4bd8f22025-08-20T02:03:16ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/259131259131Novel Insights into miRNA in Lung and Heart Inflammatory DiseasesAmit Kishore0Jana Borucka1Jana Petrkova2Martin Petrek3Laboratory of Immunogenomics and Immunoproteomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 77515 Olomouc, Czech RepublicLaboratory of Immunogenomics and Immunoproteomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 77515 Olomouc, Czech RepublicLaboratory of Immunogenomics and Immunoproteomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 77515 Olomouc, Czech RepublicLaboratory of Immunogenomics and Immunoproteomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 77515 Olomouc, Czech RepublicMicroRNAs (miRNAs) are noncoding regulatory sequences that govern posttranscriptional inhibition of genes through binding mainly at regulatory regions. The regulatory mechanism of miRNAs are influenced by complex crosstalk among single nucleotide polymorphisms (SNPs) within miRNA seed region and epigenetic modifications. Circulating miRNAs exhibit potential characteristics as stable biomarker. Functionally, miRNAs are involved in basic regulatory mechanisms of cells including inflammation. Thus, miRNA dysregulation, resulting in aberrant expression of a gene, is suggested to play an important role in disease susceptibility. This review focuses on the role of miRNA as diagnostic marker in pathogenesis of lung inflammatory diseases and in cardiac remodelling events during inflammation. From recent reports, In this context, the information about the models in which miRNAs expression were investigated including types of biological samples, as well as on the methods for miRNA validation and prediction/definition of their gene targets are emphasized in the review. Besides disease pathogenesis, promising role of miRNAs in early disease diagnosis and prognostication is also discussed. However, some miRNAs are also indicated with protective role. Thus, identifications and usage of such potential miRNAs as well as disruption of disease susceptible miRNAs using antagonists, antagomirs, are imperative and may provide a novel therapeutic approach towards combating the disease progression.http://dx.doi.org/10.1155/2014/259131 |
| spellingShingle | Amit Kishore Jana Borucka Jana Petrkova Martin Petrek Novel Insights into miRNA in Lung and Heart Inflammatory Diseases Mediators of Inflammation |
| title | Novel Insights into miRNA in Lung and Heart Inflammatory Diseases |
| title_full | Novel Insights into miRNA in Lung and Heart Inflammatory Diseases |
| title_fullStr | Novel Insights into miRNA in Lung and Heart Inflammatory Diseases |
| title_full_unstemmed | Novel Insights into miRNA in Lung and Heart Inflammatory Diseases |
| title_short | Novel Insights into miRNA in Lung and Heart Inflammatory Diseases |
| title_sort | novel insights into mirna in lung and heart inflammatory diseases |
| url | http://dx.doi.org/10.1155/2014/259131 |
| work_keys_str_mv | AT amitkishore novelinsightsintomirnainlungandheartinflammatorydiseases AT janaborucka novelinsightsintomirnainlungandheartinflammatorydiseases AT janapetrkova novelinsightsintomirnainlungandheartinflammatorydiseases AT martinpetrek novelinsightsintomirnainlungandheartinflammatorydiseases |