The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections
Kidney transplantation (KT) is a life-saving treatment for patients with end-stage renal disease, but post-transplant infections remain one of the most significant challenges. These infections, caused by a variety of pathogens, can lead to prolonged hospitalization, graft dysfunction, and even morta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1473068/full |
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| author | Hao Wu Hongliang Cao Xin Gao Chengdong Shi Lei Wang Baoshan Gao |
| author_facet | Hao Wu Hongliang Cao Xin Gao Chengdong Shi Lei Wang Baoshan Gao |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | Kidney transplantation (KT) is a life-saving treatment for patients with end-stage renal disease, but post-transplant infections remain one of the most significant challenges. These infections, caused by a variety of pathogens, can lead to prolonged hospitalization, graft dysfunction, and even mortality, particularly in immunocompromised patients. Traditional diagnostic methods often fail to identify the causative organisms in a timely manner, leading to delays in treatment and poorer patient outcomes. This review explores the application of metagenomic next-generation sequencing (mNGS) in the diagnosis of post-KT infections. mNGS allows for the rapid, comprehensive detection of a wide range of pathogens, including bacteria, viruses, fungi, and parasites, without the need for culture-based techniques. We discuss the advantages of mNGS in early and accurate pathogen identification, its role in improving patient management, and the potential challenges in its clinical implementation. Additionally, we consider the future prospects of mNGS in overcoming current diagnostic limitations and its potential for guiding targeted therapies, particularly in detecting antimicrobial resistance and emerging pathogens. This review emphasizes the promise of mNGS as an essential tool in improving the diagnosis and treatment of infections in KT recipients. |
| format | Article |
| id | doaj-art-09dbd466643149af9787656a659bfc8c |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-09dbd466643149af9787656a659bfc8c2025-01-07T06:50:34ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14730681473068The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infectionsHao WuHongliang CaoXin GaoChengdong ShiLei WangBaoshan GaoKidney transplantation (KT) is a life-saving treatment for patients with end-stage renal disease, but post-transplant infections remain one of the most significant challenges. These infections, caused by a variety of pathogens, can lead to prolonged hospitalization, graft dysfunction, and even mortality, particularly in immunocompromised patients. Traditional diagnostic methods often fail to identify the causative organisms in a timely manner, leading to delays in treatment and poorer patient outcomes. This review explores the application of metagenomic next-generation sequencing (mNGS) in the diagnosis of post-KT infections. mNGS allows for the rapid, comprehensive detection of a wide range of pathogens, including bacteria, viruses, fungi, and parasites, without the need for culture-based techniques. We discuss the advantages of mNGS in early and accurate pathogen identification, its role in improving patient management, and the potential challenges in its clinical implementation. Additionally, we consider the future prospects of mNGS in overcoming current diagnostic limitations and its potential for guiding targeted therapies, particularly in detecting antimicrobial resistance and emerging pathogens. This review emphasizes the promise of mNGS as an essential tool in improving the diagnosis and treatment of infections in KT recipients.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1473068/fullkidney transplantationmetagenomic next-generation sequencinginfectionpathogensdiagnosis |
| spellingShingle | Hao Wu Hongliang Cao Xin Gao Chengdong Shi Lei Wang Baoshan Gao The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections Frontiers in Cellular and Infection Microbiology kidney transplantation metagenomic next-generation sequencing infection pathogens diagnosis |
| title | The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections |
| title_full | The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections |
| title_fullStr | The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections |
| title_full_unstemmed | The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections |
| title_short | The role of metagenomic next-generation sequencing in diagnosing and managing post-kidney transplantation infections |
| title_sort | role of metagenomic next generation sequencing in diagnosing and managing post kidney transplantation infections |
| topic | kidney transplantation metagenomic next-generation sequencing infection pathogens diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1473068/full |
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