A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis
The primary cilium is a microtubule-based sensory cell organelle templated by a modified parent centriole that mediates mechanotransduction and response to biochemical cues such as morphogens to regulate organismal development and homeostasis. Given that the cilium is a specialized microdomain devoi...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1574638/full |
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| author | Priyanka Upadhyai Debalina Bose Neha Quadri |
| author_facet | Priyanka Upadhyai Debalina Bose Neha Quadri |
| author_sort | Priyanka Upadhyai |
| collection | DOAJ |
| description | The primary cilium is a microtubule-based sensory cell organelle templated by a modified parent centriole that mediates mechanotransduction and response to biochemical cues such as morphogens to regulate organismal development and homeostasis. Given that the cilium is a specialized microdomain devoid of its translation machinery, it relies on the endomembrane pathway for the delivery of proteins and other biomolecules to it. This review provides a comprehensive insight into how membrane trafficking modulators such as Rab and Rab-like proteins, and the exocyst complex control transport to the primary cilia, in turn regulating various aspects of their assembly and function. We integrate findings from in vitro and animal models and draw on human diseases associated with the dysfunction of Rabs or exocyst that exhibit phenotypes overlapping with those of ciliopathies, which further support their relevance to cilia biogenesis and maintenance. |
| format | Article |
| id | doaj-art-09d60126610c49e3ad3e3d05dc5ea1df |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-09d60126610c49e3ad3e3d05dc5ea1df2025-08-20T03:11:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.15746381574638A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesisPriyanka Upadhyai0Debalina Bose1Neha Quadri2Department of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaAdvanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, IndiaDepartment of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaThe primary cilium is a microtubule-based sensory cell organelle templated by a modified parent centriole that mediates mechanotransduction and response to biochemical cues such as morphogens to regulate organismal development and homeostasis. Given that the cilium is a specialized microdomain devoid of its translation machinery, it relies on the endomembrane pathway for the delivery of proteins and other biomolecules to it. This review provides a comprehensive insight into how membrane trafficking modulators such as Rab and Rab-like proteins, and the exocyst complex control transport to the primary cilia, in turn regulating various aspects of their assembly and function. We integrate findings from in vitro and animal models and draw on human diseases associated with the dysfunction of Rabs or exocyst that exhibit phenotypes overlapping with those of ciliopathies, which further support their relevance to cilia biogenesis and maintenance.https://www.frontiersin.org/articles/10.3389/fcell.2025.1574638/fullprimary ciliaRabsRab-like proteinsexocystciliary traffickingciliopathies |
| spellingShingle | Priyanka Upadhyai Debalina Bose Neha Quadri A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis Frontiers in Cell and Developmental Biology primary cilia Rabs Rab-like proteins exocyst ciliary trafficking ciliopathies |
| title | A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis |
| title_full | A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis |
| title_fullStr | A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis |
| title_full_unstemmed | A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis |
| title_short | A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis |
| title_sort | tale of rabs and the exocyst complex in ciliary trafficking and biogenesis |
| topic | primary cilia Rabs Rab-like proteins exocyst ciliary trafficking ciliopathies |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1574638/full |
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