Distinct prognostic values of YAP1 in gastric cancer
The Hippo pathway regulates intrinsic organ sizes by regulating apoptosis and cell proliferation. YAP1 (yes-associated protein 1) is a transcriptional effector of the Hippo pathway. YAP1 expression is reported to be associated with gastric cancer carcinogenesis and malignancy. In this study, we comp...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-04-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695926 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849417409749843968 |
|---|---|
| author | Lan Yu Chun Gao Bei Feng Liming Wang Xun Tian Hui Wang Ding Ma |
| author_facet | Lan Yu Chun Gao Bei Feng Liming Wang Xun Tian Hui Wang Ding Ma |
| author_sort | Lan Yu |
| collection | DOAJ |
| description | The Hippo pathway regulates intrinsic organ sizes by regulating apoptosis and cell proliferation. YAP1 (yes-associated protein 1) is a transcriptional effector of the Hippo pathway. YAP1 expression is reported to be associated with gastric cancer carcinogenesis and malignancy. In this study, we compared the expression of YAP1 in gastric cancer and normal stomach tissues. Tissue microarray analysis was performed in 156 gastric cancer samples, 8 adjacent normal stomach tissues, and 4 normal stomach tissues. We also analyzed the association between YAP1 protein expression and clinicopathological features, such as age, gender, histological differentiation, and clinical stages. We used the ONCOMINE database and the Kaplan–Meier plotter to analyze YAP1 expression status in different clinicopathological parameters of gastric cancer. We also used the Kaplan–Meier plotter to summarize the survival information of YAP1 from a total of 631 gastric cancer patients. YAP1 expression was found to be elevated in gastric cancer tissues compared to normal stomach tissues. YAP1 messenger RNA was found to be upregulated in gastric intestinal-type adenocarcinoma and gastric mixed adenocarcinoma compared to gastric mucosa. YAP1 high expression was found to be correlated to worse overall survival for all gastric cancer patients followed for 20 years. These results indicate that YAP1 can be used to predict the prognosis of gastric cancer. And YAP1 maybe a potential drug target for gastric cancer patients. |
| format | Article |
| id | doaj-art-09d5cc81440b41479e2685bd723e73c0 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-09d5cc81440b41479e2685bd723e73c02025-08-20T03:32:51ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317695926Distinct prognostic values of YAP1 in gastric cancerLan Yu0Chun Gao1Bei Feng2Liming Wang3Xun Tian4Hui Wang5Ding Ma6Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaThe Hippo pathway regulates intrinsic organ sizes by regulating apoptosis and cell proliferation. YAP1 (yes-associated protein 1) is a transcriptional effector of the Hippo pathway. YAP1 expression is reported to be associated with gastric cancer carcinogenesis and malignancy. In this study, we compared the expression of YAP1 in gastric cancer and normal stomach tissues. Tissue microarray analysis was performed in 156 gastric cancer samples, 8 adjacent normal stomach tissues, and 4 normal stomach tissues. We also analyzed the association between YAP1 protein expression and clinicopathological features, such as age, gender, histological differentiation, and clinical stages. We used the ONCOMINE database and the Kaplan–Meier plotter to analyze YAP1 expression status in different clinicopathological parameters of gastric cancer. We also used the Kaplan–Meier plotter to summarize the survival information of YAP1 from a total of 631 gastric cancer patients. YAP1 expression was found to be elevated in gastric cancer tissues compared to normal stomach tissues. YAP1 messenger RNA was found to be upregulated in gastric intestinal-type adenocarcinoma and gastric mixed adenocarcinoma compared to gastric mucosa. YAP1 high expression was found to be correlated to worse overall survival for all gastric cancer patients followed for 20 years. These results indicate that YAP1 can be used to predict the prognosis of gastric cancer. And YAP1 maybe a potential drug target for gastric cancer patients.https://doi.org/10.1177/1010428317695926 |
| spellingShingle | Lan Yu Chun Gao Bei Feng Liming Wang Xun Tian Hui Wang Ding Ma Distinct prognostic values of YAP1 in gastric cancer Tumor Biology |
| title | Distinct prognostic values of YAP1 in gastric cancer |
| title_full | Distinct prognostic values of YAP1 in gastric cancer |
| title_fullStr | Distinct prognostic values of YAP1 in gastric cancer |
| title_full_unstemmed | Distinct prognostic values of YAP1 in gastric cancer |
| title_short | Distinct prognostic values of YAP1 in gastric cancer |
| title_sort | distinct prognostic values of yap1 in gastric cancer |
| url | https://doi.org/10.1177/1010428317695926 |
| work_keys_str_mv | AT lanyu distinctprognosticvaluesofyap1ingastriccancer AT chungao distinctprognosticvaluesofyap1ingastriccancer AT beifeng distinctprognosticvaluesofyap1ingastriccancer AT limingwang distinctprognosticvaluesofyap1ingastriccancer AT xuntian distinctprognosticvaluesofyap1ingastriccancer AT huiwang distinctprognosticvaluesofyap1ingastriccancer AT dingma distinctprognosticvaluesofyap1ingastriccancer |