Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies
Abstract Background Atherogenic index of plasma (AIP), a novel logarithmic index that combines fasting triglyceride and high-density lipoprotein cholesterol concentrations, is associated with the burden of atherosclerosis. This study aimed to evaluate the relationship between AIP and coronary artery...
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BMC
2025-01-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02582-2 |
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| author | Ramin Assempoor Mohammad Shahabaddin Daneshvar Aryan Taghvaei Alireza Sattari Abroy Amir Azimi John R. Nelson Kaveh Hosseini |
| author_facet | Ramin Assempoor Mohammad Shahabaddin Daneshvar Aryan Taghvaei Alireza Sattari Abroy Amir Azimi John R. Nelson Kaveh Hosseini |
| author_sort | Ramin Assempoor |
| collection | DOAJ |
| description | Abstract Background Atherogenic index of plasma (AIP), a novel logarithmic index that combines fasting triglyceride and high-density lipoprotein cholesterol concentrations, is associated with the burden of atherosclerosis. This study aimed to evaluate the relationship between AIP and coronary artery disease (CAD) risk, severity, and prognosis in populations with and without established CAD. Methods PubMed, Embase, and Web of Science were systematically searched from the inception of each database to August 13, 2024. Cross-sectional studies, case-control studies, and prospective or retrospective cohort studies using multivariate analysis were included. Given that the true effect size may differ across studies, a random-effects model for all analyses was applied. Results Fifty-one observational studies were included in this study. Patients with higher AIP were more likely to have CAD (odds ratio (OR): 2.79, 95% CI 1.75–4.45, P < 0.00001). Furthermore, these patients were more likely to have coronary artery calcification (OR: 2.28, 95% CI 1.74–3.00, P < 0.00001), multivessel CAD (OR: 2.04, 95% CI 1.50–2.77, P < 0.00001), and an increased risk of plaque progression (OR: 1.49, 95% CI 1.17–1.91, P = 0.001). In populations without established CAD, higher AIP levels were associated with an increased risk of Major adverse cardiovascular events (MACE) (hazard ratio (HR): 1.28, 95% CI 1.22–1.35, P < 0.00001). Interestingly, this finding was consistent in patients presenting with acute coronary syndrome (HR: 1.59, 95% CI 1.33–1.89, P < 0.00001) and patients with chronic coronary syndrome or stable CAD (HR: 1.65, 95% CI 1.15–2.37, P = 0.007). Conclusions This meta-analysis demonstrates that elevated AIP is strongly associated with increased CAD risk, greater severity, and poorer prognosis in populations with and without established CAD. However, more studies are needed to evaluate the predictive performance and determine the optimal cut-off for AIP in different populations. Graphical abstract |
| format | Article |
| id | doaj-art-09d29c1c0acf490bbde1cee2e574c00e |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-09d29c1c0acf490bbde1cee2e574c00e2025-01-26T12:13:38ZengBMCCardiovascular Diabetology1475-28402025-01-0124112310.1186/s12933-025-02582-2Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studiesRamin Assempoor0Mohammad Shahabaddin Daneshvar1Aryan Taghvaei2Alireza Sattari Abroy3Amir Azimi4John R. Nelson5Kaveh Hosseini6Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical SciencesCardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical SciencesCardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical SciencesCardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical SciencesRajaie Cardiovascular Medical and Research Center, Iran University of Medical SciencesCalifornia Cardiovascular InstituteCardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical SciencesAbstract Background Atherogenic index of plasma (AIP), a novel logarithmic index that combines fasting triglyceride and high-density lipoprotein cholesterol concentrations, is associated with the burden of atherosclerosis. This study aimed to evaluate the relationship between AIP and coronary artery disease (CAD) risk, severity, and prognosis in populations with and without established CAD. Methods PubMed, Embase, and Web of Science were systematically searched from the inception of each database to August 13, 2024. Cross-sectional studies, case-control studies, and prospective or retrospective cohort studies using multivariate analysis were included. Given that the true effect size may differ across studies, a random-effects model for all analyses was applied. Results Fifty-one observational studies were included in this study. Patients with higher AIP were more likely to have CAD (odds ratio (OR): 2.79, 95% CI 1.75–4.45, P < 0.00001). Furthermore, these patients were more likely to have coronary artery calcification (OR: 2.28, 95% CI 1.74–3.00, P < 0.00001), multivessel CAD (OR: 2.04, 95% CI 1.50–2.77, P < 0.00001), and an increased risk of plaque progression (OR: 1.49, 95% CI 1.17–1.91, P = 0.001). In populations without established CAD, higher AIP levels were associated with an increased risk of Major adverse cardiovascular events (MACE) (hazard ratio (HR): 1.28, 95% CI 1.22–1.35, P < 0.00001). Interestingly, this finding was consistent in patients presenting with acute coronary syndrome (HR: 1.59, 95% CI 1.33–1.89, P < 0.00001) and patients with chronic coronary syndrome or stable CAD (HR: 1.65, 95% CI 1.15–2.37, P = 0.007). Conclusions This meta-analysis demonstrates that elevated AIP is strongly associated with increased CAD risk, greater severity, and poorer prognosis in populations with and without established CAD. However, more studies are needed to evaluate the predictive performance and determine the optimal cut-off for AIP in different populations. Graphical abstracthttps://doi.org/10.1186/s12933-025-02582-2Atherogenic index of plasmaCoronary artery diseasePrognosisSeverityRiskOutcomes |
| spellingShingle | Ramin Assempoor Mohammad Shahabaddin Daneshvar Aryan Taghvaei Alireza Sattari Abroy Amir Azimi John R. Nelson Kaveh Hosseini Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies Cardiovascular Diabetology Atherogenic index of plasma Coronary artery disease Prognosis Severity Risk Outcomes |
| title | Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies |
| title_full | Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies |
| title_fullStr | Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies |
| title_short | Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies |
| title_sort | atherogenic index of plasma and coronary artery disease a systematic review and meta analysis of observational studies |
| topic | Atherogenic index of plasma Coronary artery disease Prognosis Severity Risk Outcomes |
| url | https://doi.org/10.1186/s12933-025-02582-2 |
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