Automated method for quantification of 20 amino acids in cell culture media during biopharmaceutical development

Herein, a step-by-step protocol for simultaneous detection of 20 amino acids commonly present in cell culture media is described. The protocol facilitates detection of both primary and secondary amino acids through a two-step precolumn derivatization strategy using ortho-phthalaldehyde and 9-fluoren...

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Bibliographic Details
Main Authors: Ankita Dubey, Srishti Joshi, Kratika Upadhyay, Ansuman Mahato, Anurag S Rathore
Format: Article
Language:English
Published: Taylor & Francis Group 2024-01-01
Series:BioTechniques
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Online Access:https://www.future-science.com/doi/10.2144/btn-2023-0068
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