A cortico-subcortical loop for motor control via the pontine reticular formation
Summary: Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000014 |
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| author | Emília Bősz Viktor M. Plattner László Biró Kata Kóta Marco A. Diana László Acsády |
| author_facet | Emília Bősz Viktor M. Plattner László Biró Kata Kóta Marco A. Diana László Acsády |
| author_sort | Emília Bősz |
| collection | DOAJ |
| description | Summary: Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist is presently unclear. Here, we demonstrate that the secondary motor and cingulate cortices (M2/Cg) target and strongly control the activity of glycine transporter 2-positive (GlyT2+) cells in the pontine reticular formation (PRF). In turn, PRF/GlyT2+ cells project to and powerfully inhibit the intralaminar/parafascicular nuclei of the thalamus (IL/Pf). M2/Cg cells co-innervate PRF/GlyT2+ cells and the IL/Pf. Thalamus-projecting PRF/GlyT2+ cells target ipsilateral subcortical regions distinct from BG targets. Activation of the thalamus-projecting PRF/GlyT2+ cells leads to contralateral turning. These results demonstrate that the PRF is part of a cortico-subcortical loop that regulates motor activity parallel to BG circuits. The cortico-PRF-thalamus loop can control turning synergistically with the BG loops via distinct descending pathways. |
| format | Article |
| id | doaj-art-09cd51aa232c428a8f7a4cf570f0a83d |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-09cd51aa232c428a8f7a4cf570f0a83d2025-01-23T05:26:38ZengElsevierCell Reports2211-12472025-02-01442115230A cortico-subcortical loop for motor control via the pontine reticular formationEmília Bősz0Viktor M. Plattner1László Biró2Kata Kóta3Marco A. Diana4László Acsády5Lendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, 1083 Budapest, HungaryLendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary; Sainsbury Wellcome Ctr., London W1T 4JG, UKLendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, HungaryLendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary; Semmelweis University, 1083 Budapest, HungaryUniversité Paris Cité, CNRS, Saint-Pères Paris Institute for the Neurosciences, 75006 Paris, FranceLendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary; Corresponding authorSummary: Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist is presently unclear. Here, we demonstrate that the secondary motor and cingulate cortices (M2/Cg) target and strongly control the activity of glycine transporter 2-positive (GlyT2+) cells in the pontine reticular formation (PRF). In turn, PRF/GlyT2+ cells project to and powerfully inhibit the intralaminar/parafascicular nuclei of the thalamus (IL/Pf). M2/Cg cells co-innervate PRF/GlyT2+ cells and the IL/Pf. Thalamus-projecting PRF/GlyT2+ cells target ipsilateral subcortical regions distinct from BG targets. Activation of the thalamus-projecting PRF/GlyT2+ cells leads to contralateral turning. These results demonstrate that the PRF is part of a cortico-subcortical loop that regulates motor activity parallel to BG circuits. The cortico-PRF-thalamus loop can control turning synergistically with the BG loops via distinct descending pathways.http://www.sciencedirect.com/science/article/pii/S2211124725000014CP: Neuroscience |
| spellingShingle | Emília Bősz Viktor M. Plattner László Biró Kata Kóta Marco A. Diana László Acsády A cortico-subcortical loop for motor control via the pontine reticular formation Cell Reports CP: Neuroscience |
| title | A cortico-subcortical loop for motor control via the pontine reticular formation |
| title_full | A cortico-subcortical loop for motor control via the pontine reticular formation |
| title_fullStr | A cortico-subcortical loop for motor control via the pontine reticular formation |
| title_full_unstemmed | A cortico-subcortical loop for motor control via the pontine reticular formation |
| title_short | A cortico-subcortical loop for motor control via the pontine reticular formation |
| title_sort | cortico subcortical loop for motor control via the pontine reticular formation |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000014 |
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