Heart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain.

Heart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain.

Oxidative stress promotes T. cruzi growth and development of chronic Chagas heart dysfunction. However, the literature contains gaps that must be fulfilled, largely due to variations in parasite DTU sources, cell types, mouse strains, and tools to manipulate redox status. We assessed the impact of o...

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Main Authors: Hilton Antônio Mata-Santos, Camila Victória Sousa Oliveira, Daniel F Feijo, Daniel Figueiredo Vanzan, Glaucia Vilar-Pereira, Isalira P Ramos, Vitor Coutinho Carneiro, Oscar Moreno-Loaiza, Jaline Coutinho Silverio, Joseli Lannes-Vieira, Emiliano Medei, Marcelo T Bozza, Claudia N Paiva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012612
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