SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE
Aim. This work aims to study the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS).Material and methods. 120 AIS patients were included in this study. There were 3 groups as below: Group A (tirofiban alone, n=68), Group B (tirofiban plus thrombolytic...
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| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/602 |
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| _version_ | 1849250818186805248 |
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| author | Yan-Jun Zhang Qing Liu Qin Zhan Qiong Li |
| author_facet | Yan-Jun Zhang Qing Liu Qin Zhan Qiong Li |
| author_sort | Yan-Jun Zhang |
| collection | DOAJ |
| description | Aim. This work aims to study the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS).Material and methods. 120 AIS patients were included in this study. There were 3 groups as below: Group A (tirofiban alone, n=68), Group B (tirofiban plus thrombolytic therapy, n=26), and Group C (tirofiban plus bridging therapy, n=26). Risk factors, stroke severity, initial imaging, treatment regimens, complications and longterm outcomes were analyzed.Results. Eight patients (6,7%) in Group A, 6 patients (23,1%) in Group B and 2 patients (7,7%) in Group C had hemorrhage during or after treatment. Sixteen patients (6 in Group A, 8 in Group B and 2 in Group C) died during hospital admission. The mortality rate was 13,3% (8,8% for Group A, 30,7% for Group B and 7,7% for Group C, respectively) in the acute phase. A favorable outcome (mRS 0–2) at the first three months after stroke was only observed in 43,3% of patients (44,1% in Group A, 46,7% in Group B and 36,4% in Group C). The average Barthel index was 72,3 in Group A, 84,4 in Group B and 56,8 in Group C (total score: 71,0).Conclusion. The stroke treatment with tirofiban is safe in AIS. A large randomized controlled trial in the future will be needed to decrease the minor bleeding complication of tirofiban therapy. |
| format | Article |
| id | doaj-art-09ccb80d1fd449e3aa4a06c33628c8a2 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2014-04-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-09ccb80d1fd449e3aa4a06c33628c8a22025-08-20T03:57:09Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-04-0104-ENG222710.15829/1560-4071-2014-4-ENG-22-27549SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICEYan-Jun Zhang0Qing Liu1Qin Zhan2Qiong Li3Department of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, ChinaAim. This work aims to study the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS).Material and methods. 120 AIS patients were included in this study. There were 3 groups as below: Group A (tirofiban alone, n=68), Group B (tirofiban plus thrombolytic therapy, n=26), and Group C (tirofiban plus bridging therapy, n=26). Risk factors, stroke severity, initial imaging, treatment regimens, complications and longterm outcomes were analyzed.Results. Eight patients (6,7%) in Group A, 6 patients (23,1%) in Group B and 2 patients (7,7%) in Group C had hemorrhage during or after treatment. Sixteen patients (6 in Group A, 8 in Group B and 2 in Group C) died during hospital admission. The mortality rate was 13,3% (8,8% for Group A, 30,7% for Group B and 7,7% for Group C, respectively) in the acute phase. A favorable outcome (mRS 0–2) at the first three months after stroke was only observed in 43,3% of patients (44,1% in Group A, 46,7% in Group B and 36,4% in Group C). The average Barthel index was 72,3 in Group A, 84,4 in Group B and 56,8 in Group C (total score: 71,0).Conclusion. The stroke treatment with tirofiban is safe in AIS. A large randomized controlled trial in the future will be needed to decrease the minor bleeding complication of tirofiban therapy.https://russjcardiol.elpub.ru/jour/article/view/602tirofibanacute ischemic strokesafety |
| spellingShingle | Yan-Jun Zhang Qing Liu Qin Zhan Qiong Li SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE Российский кардиологический журнал tirofiban acute ischemic stroke safety |
| title | SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE |
| title_full | SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE |
| title_fullStr | SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE |
| title_full_unstemmed | SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE |
| title_short | SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE |
| title_sort | safety of tirofiban for patients with acute ischemic stroke in routine clinical practice |
| topic | tirofiban acute ischemic stroke safety |
| url | https://russjcardiol.elpub.ru/jour/article/view/602 |
| work_keys_str_mv | AT yanjunzhang safetyoftirofibanforpatientswithacuteischemicstrokeinroutineclinicalpractice AT qingliu safetyoftirofibanforpatientswithacuteischemicstrokeinroutineclinicalpractice AT qinzhan safetyoftirofibanforpatientswithacuteischemicstrokeinroutineclinicalpractice AT qiongli safetyoftirofibanforpatientswithacuteischemicstrokeinroutineclinicalpractice |