Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
Lenalidomide is a synthetic compound derived by modifying the chemical structure of thalidomide. It belongs to the second generation of immunomodulatory drugs (IMiDs) and possesses pleiotropic properties. Even if lenalidomide has been shown to be active in the treatment of several hematologic malign...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/842945 |
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| author | Roberta Martiniani Valentina Di Loreto Chiara Di Sano Alessandra Lombardo Anna Marina Liberati |
| author_facet | Roberta Martiniani Valentina Di Loreto Chiara Di Sano Alessandra Lombardo Anna Marina Liberati |
| author_sort | Roberta Martiniani |
| collection | DOAJ |
| description | Lenalidomide is a synthetic compound derived by modifying the chemical structure of thalidomide. It belongs to the second generation of immunomodulatory drugs (IMiDs) and possesses pleiotropic properties. Even if lenalidomide has been shown to be active in the treatment of several hematologic malignancies, this review article is mostly focalized on its mode of action in multiple myeloma. The present paper is about the direct and indirect antitumor effects of lenalidomide on malignant plasmacells, bone marrow microenvironment, bone resorption and host’s immune response. The molecular mechanisms and targets of lenalidomide remain largely unknown, but recent evidence shows cereblon (CRBN) as a possible mediator of its therapeutical effects. |
| format | Article |
| id | doaj-art-09c1d03a18744bfc8db84f2e66b9d599 |
| institution | OA Journals |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-09c1d03a18744bfc8db84f2e66b9d5992025-08-20T02:03:16ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/842945842945Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple MyelomaRoberta Martiniani0Valentina Di Loreto1Chiara Di Sano2Alessandra Lombardo3Anna Marina Liberati4Department of Oncohematology, University of Perugia, Santa Maria Hospital, 05100 Terni, ItalyDepartment of Oncohematology, University of Perugia, Santa Maria Hospital, 05100 Terni, ItalyDepartment of Oncohematology, University of Perugia, Santa Maria Hospital, 05100 Terni, ItalyDepartment of Oncohematology, University of Perugia, Santa Maria Hospital, 05100 Terni, ItalyDepartment of Oncohematology, University of Perugia, Santa Maria Hospital, 05100 Terni, ItalyLenalidomide is a synthetic compound derived by modifying the chemical structure of thalidomide. It belongs to the second generation of immunomodulatory drugs (IMiDs) and possesses pleiotropic properties. Even if lenalidomide has been shown to be active in the treatment of several hematologic malignancies, this review article is mostly focalized on its mode of action in multiple myeloma. The present paper is about the direct and indirect antitumor effects of lenalidomide on malignant plasmacells, bone marrow microenvironment, bone resorption and host’s immune response. The molecular mechanisms and targets of lenalidomide remain largely unknown, but recent evidence shows cereblon (CRBN) as a possible mediator of its therapeutical effects.http://dx.doi.org/10.1155/2012/842945 |
| spellingShingle | Roberta Martiniani Valentina Di Loreto Chiara Di Sano Alessandra Lombardo Anna Marina Liberati Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma Advances in Hematology |
| title | Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma |
| title_full | Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma |
| title_fullStr | Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma |
| title_full_unstemmed | Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma |
| title_short | Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma |
| title_sort | biological activity of lenalidomide and its underlying therapeutic effects in multiple myeloma |
| url | http://dx.doi.org/10.1155/2012/842945 |
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