Fibroin-Hybrid Systems: Current Advances in Biomedical Applications
Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/328 |
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| author | Matheus Valentin Maia Eryvaldo Sócrates Tabosa do Egito Anne Sapin-Minet Daniel Bragança Viana Ashok Kakkar Daniel Crístian Ferreira Soares |
| author_facet | Matheus Valentin Maia Eryvaldo Sócrates Tabosa do Egito Anne Sapin-Minet Daniel Bragança Viana Ashok Kakkar Daniel Crístian Ferreira Soares |
| author_sort | Matheus Valentin Maia |
| collection | DOAJ |
| description | Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates. This review article brings into focus applications of fibroin-hybrid systems prepared using chemical modification of the protein with polymers and inorganic compounds. A selection of recent preclinical evaluations of these hybrids is included to highlight the significance of this approach. |
| format | Article |
| id | doaj-art-09b355711ca54e7fbb1a3980dd846f9b |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-09b355711ca54e7fbb1a3980dd846f9b2025-01-24T13:43:38ZengMDPI AGMolecules1420-30492025-01-0130232810.3390/molecules30020328Fibroin-Hybrid Systems: Current Advances in Biomedical ApplicationsMatheus Valentin Maia0Eryvaldo Sócrates Tabosa do Egito1Anne Sapin-Minet2Daniel Bragança Viana3Ashok Kakkar4Daniel Crístian Ferreira Soares5Laboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, BrazilLaboratório de Sistemas Dispersos LaSiD, Faculdade de Farmácia, Universidade Federal do Rio Grande no Norte, Natal 59012-570, Rio Grande do Norte, BrazilFaculté de Pharmacie, Université de Lorraine, CITHEFOR, F-54000 Nancy, FranceLaboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, BrazilDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, QC H3A 0B8, CanadaLaboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, BrazilFibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates. This review article brings into focus applications of fibroin-hybrid systems prepared using chemical modification of the protein with polymers and inorganic compounds. A selection of recent preclinical evaluations of these hybrids is included to highlight the significance of this approach.https://www.mdpi.com/1420-3049/30/2/328silk fibroinhybrid systemsurface-grafting polymerizationchemical modificationbiomedical applications |
| spellingShingle | Matheus Valentin Maia Eryvaldo Sócrates Tabosa do Egito Anne Sapin-Minet Daniel Bragança Viana Ashok Kakkar Daniel Crístian Ferreira Soares Fibroin-Hybrid Systems: Current Advances in Biomedical Applications Molecules silk fibroin hybrid system surface-grafting polymerization chemical modification biomedical applications |
| title | Fibroin-Hybrid Systems: Current Advances in Biomedical Applications |
| title_full | Fibroin-Hybrid Systems: Current Advances in Biomedical Applications |
| title_fullStr | Fibroin-Hybrid Systems: Current Advances in Biomedical Applications |
| title_full_unstemmed | Fibroin-Hybrid Systems: Current Advances in Biomedical Applications |
| title_short | Fibroin-Hybrid Systems: Current Advances in Biomedical Applications |
| title_sort | fibroin hybrid systems current advances in biomedical applications |
| topic | silk fibroin hybrid system surface-grafting polymerization chemical modification biomedical applications |
| url | https://www.mdpi.com/1420-3049/30/2/328 |
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