TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights
Abstract TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic modifications, as well as in hematopoiesis. Mutations in TET2 are present in 7%–28% of adult acute myeloid leukemia (A...
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| Language: | English |
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BMC
2024-11-01
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| Series: | Clinical Epigenetics |
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| Online Access: | https://doi.org/10.1186/s13148-024-01771-2 |
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| author | Qiang Gao Kefeng Shen Min Xiao |
| author_facet | Qiang Gao Kefeng Shen Min Xiao |
| author_sort | Qiang Gao |
| collection | DOAJ |
| description | Abstract TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic modifications, as well as in hematopoiesis. Mutations in TET2 are present in 7%–28% of adult acute myeloid leukemia (AML) patients. Despite this, the precise mechanisms by which TET2 mutations contribute to malignant transformation and how these insights can be leveraged to enhance treatment strategies for AML patients with TET2 mutations remain unclear. In this review, we provide an overview of the functions of TET2, the effects of its mutations, its role in clonal hematopoiesis, and the possible mechanisms of leukemogenesis. Additionally, we explore the mutational landscape across different AML subtypes and present recent promising preclinical research findings. |
| format | Article |
| id | doaj-art-09b07bb662b64155a61da8aab73ef7b5 |
| institution | Kabale University |
| issn | 1868-7083 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-09b07bb662b64155a61da8aab73ef7b52024-11-10T12:30:42ZengBMCClinical Epigenetics1868-70832024-11-0116111310.1186/s13148-024-01771-2TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insightsQiang Gao0Kefeng Shen1Min Xiao2Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic modifications, as well as in hematopoiesis. Mutations in TET2 are present in 7%–28% of adult acute myeloid leukemia (AML) patients. Despite this, the precise mechanisms by which TET2 mutations contribute to malignant transformation and how these insights can be leveraged to enhance treatment strategies for AML patients with TET2 mutations remain unclear. In this review, we provide an overview of the functions of TET2, the effects of its mutations, its role in clonal hematopoiesis, and the possible mechanisms of leukemogenesis. Additionally, we explore the mutational landscape across different AML subtypes and present recent promising preclinical research findings.https://doi.org/10.1186/s13148-024-01771-2TET2Acute myeloid leukemiaDNA methylationMechanismsTherapeutic insights |
| spellingShingle | Qiang Gao Kefeng Shen Min Xiao TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights Clinical Epigenetics TET2 Acute myeloid leukemia DNA methylation Mechanisms Therapeutic insights |
| title | TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights |
| title_full | TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights |
| title_fullStr | TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights |
| title_full_unstemmed | TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights |
| title_short | TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights |
| title_sort | tet2 mutation in acute myeloid leukemia biology clinical significance and therapeutic insights |
| topic | TET2 Acute myeloid leukemia DNA methylation Mechanisms Therapeutic insights |
| url | https://doi.org/10.1186/s13148-024-01771-2 |
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