Research progress of circRNAs in bone-related diseases
Circular RNAs (circRNAs) are non-coding RNAs that exist naturally in various eukaryotic organisms. The majority of circRNAs are produced through the splicing of exons, although there are a limited number that are generated through the circularization of introns. Studies have shown that circRNAs play...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1481322/full |
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| author | Xianming Hua Lingfeng Yu Hao Zhu Yan Zhu Gentao Fan Guangxin Zhou Guangxin Zhou Guangxin Zhou |
| author_facet | Xianming Hua Lingfeng Yu Hao Zhu Yan Zhu Gentao Fan Guangxin Zhou Guangxin Zhou Guangxin Zhou |
| author_sort | Xianming Hua |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are non-coding RNAs that exist naturally in various eukaryotic organisms. The majority of circRNAs are produced through the splicing of exons, although there are a limited number that are generated through the circularization of introns. Studies have shown that circRNAs play an irreplaceable role in the pathogenesis, disease progression, diagnosis, and targeted therapy of motor system tumors (osteosarcoma), metabolic diseases (osteoporosis), and degenerative diseases (osteonecrosis of the femoral head, osteoarthritis, intervertebral disc degeneration). This review summarizes the advancements in circRNA detection techniques and the research progress of circRNAs in orthopedic diseases. |
| format | Article |
| id | doaj-art-09aa46ffa7214b22b386e75a37f70b08 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-09aa46ffa7214b22b386e75a37f70b082025-01-27T06:40:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14813221481322Research progress of circRNAs in bone-related diseasesXianming Hua0Lingfeng Yu1Hao Zhu2Yan Zhu3Gentao Fan4Guangxin Zhou5Guangxin Zhou6Guangxin Zhou7Department of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Life Sciences, Nanjing University, Nanjing, Jiangsu, ChinaDepartment of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, ChinaWuxi Xishan Nanjing University (NJU) Institute of Applied Biotechnology, Wuxi, Jiangsu, ChinaCircular RNAs (circRNAs) are non-coding RNAs that exist naturally in various eukaryotic organisms. The majority of circRNAs are produced through the splicing of exons, although there are a limited number that are generated through the circularization of introns. Studies have shown that circRNAs play an irreplaceable role in the pathogenesis, disease progression, diagnosis, and targeted therapy of motor system tumors (osteosarcoma), metabolic diseases (osteoporosis), and degenerative diseases (osteonecrosis of the femoral head, osteoarthritis, intervertebral disc degeneration). This review summarizes the advancements in circRNA detection techniques and the research progress of circRNAs in orthopedic diseases.https://www.frontiersin.org/articles/10.3389/fonc.2025.1481322/fullcircRNAsnon-coding RNAsorthopedic diseasestherapeutic targetbiomarker |
| spellingShingle | Xianming Hua Lingfeng Yu Hao Zhu Yan Zhu Gentao Fan Guangxin Zhou Guangxin Zhou Guangxin Zhou Research progress of circRNAs in bone-related diseases Frontiers in Oncology circRNAs non-coding RNAs orthopedic diseases therapeutic target biomarker |
| title | Research progress of circRNAs in bone-related diseases |
| title_full | Research progress of circRNAs in bone-related diseases |
| title_fullStr | Research progress of circRNAs in bone-related diseases |
| title_full_unstemmed | Research progress of circRNAs in bone-related diseases |
| title_short | Research progress of circRNAs in bone-related diseases |
| title_sort | research progress of circrnas in bone related diseases |
| topic | circRNAs non-coding RNAs orthopedic diseases therapeutic target biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1481322/full |
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