Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?

Advanced carotid disease is known to be associated with symptomatic cerebrovascular diseases, such as stroke or transient ischemic attack (TIA), as well as with poststroke cognitive impairment. However, cognitive decline often occurs in patients with advanced carotid stenosis without clinically evid...

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Main Authors: Irena Martinić-Popović, Arijana Lovrenčić-Huzjan, Vida Demarin
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Stroke Research and Treatment
Online Access:http://dx.doi.org/10.1155/2012/981416
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author Irena Martinić-Popović
Arijana Lovrenčić-Huzjan
Vida Demarin
author_facet Irena Martinić-Popović
Arijana Lovrenčić-Huzjan
Vida Demarin
author_sort Irena Martinić-Popović
collection DOAJ
description Advanced carotid disease is known to be associated with symptomatic cerebrovascular diseases, such as stroke or transient ischemic attack (TIA), as well as with poststroke cognitive impairment. However, cognitive decline often occurs in patients with advanced carotid stenosis without clinically evident stroke or TIA, so it is also suspected to be an independent risk factor for dementia. Neurosonological methods enable simple and noninvasive assessment of carotid stenosis in patients at risk of advanced atherosclerosis. Cognitive status in patients diagnosed with advanced carotid stenosis is routinely not taken into consideration, although if cognitive impairment is present, such patients should probably be called symptomatic. In this paper, we discuss results of some most important studies that investigated cognitive status of patients with asymptomatic advanced carotid disease and possible mechanisms involved in the causal relationship between asymptomatic advanced carotid disease and cognitive decline.
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spelling doaj-art-09a93d86720148cc988a0cd8799c98eb2025-02-03T05:45:51ZengWileyStroke Research and Treatment2090-81052042-00562012-01-01201210.1155/2012/981416981416Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?Irena Martinić-Popović0Arijana Lovrenčić-Huzjan1Vida Demarin2University Department of Neurology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaUniversity Department of Neurology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaUniversity Department of Neurology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaAdvanced carotid disease is known to be associated with symptomatic cerebrovascular diseases, such as stroke or transient ischemic attack (TIA), as well as with poststroke cognitive impairment. However, cognitive decline often occurs in patients with advanced carotid stenosis without clinically evident stroke or TIA, so it is also suspected to be an independent risk factor for dementia. Neurosonological methods enable simple and noninvasive assessment of carotid stenosis in patients at risk of advanced atherosclerosis. Cognitive status in patients diagnosed with advanced carotid stenosis is routinely not taken into consideration, although if cognitive impairment is present, such patients should probably be called symptomatic. In this paper, we discuss results of some most important studies that investigated cognitive status of patients with asymptomatic advanced carotid disease and possible mechanisms involved in the causal relationship between asymptomatic advanced carotid disease and cognitive decline.http://dx.doi.org/10.1155/2012/981416
spellingShingle Irena Martinić-Popović
Arijana Lovrenčić-Huzjan
Vida Demarin
Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?
Stroke Research and Treatment
title Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?
title_full Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?
title_fullStr Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?
title_full_unstemmed Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?
title_short Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link?
title_sort advanced asymptomatic carotid disease and cognitive impairment an understated link
url http://dx.doi.org/10.1155/2012/981416
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