Feedback control architecture and the bacterial chemotaxis network.
Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteri...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-05-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001130&type=printable |
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| _version_ | 1849726873566707712 |
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| author | Abdullah Hamadeh Mark A J Roberts Elias August Patrick E McSharry Philip K Maini Judith P Armitage Antonis Papachristodoulou |
| author_facet | Abdullah Hamadeh Mark A J Roberts Elias August Patrick E McSharry Philip K Maini Judith P Armitage Antonis Papachristodoulou |
| author_sort | Abdullah Hamadeh |
| collection | DOAJ |
| description | Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a 'cascade control' feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance. |
| format | Article |
| id | doaj-art-09a8c98e8f2f46459f9cdc9773f0d62b |
| institution | DOAJ |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2011-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-09a8c98e8f2f46459f9cdc9773f0d62b2025-08-20T03:10:02ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582011-05-0175e100113010.1371/journal.pcbi.1001130Feedback control architecture and the bacterial chemotaxis network.Abdullah HamadehMark A J RobertsElias AugustPatrick E McSharryPhilip K MainiJudith P ArmitageAntonis PapachristodoulouBacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a 'cascade control' feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001130&type=printable |
| spellingShingle | Abdullah Hamadeh Mark A J Roberts Elias August Patrick E McSharry Philip K Maini Judith P Armitage Antonis Papachristodoulou Feedback control architecture and the bacterial chemotaxis network. PLoS Computational Biology |
| title | Feedback control architecture and the bacterial chemotaxis network. |
| title_full | Feedback control architecture and the bacterial chemotaxis network. |
| title_fullStr | Feedback control architecture and the bacterial chemotaxis network. |
| title_full_unstemmed | Feedback control architecture and the bacterial chemotaxis network. |
| title_short | Feedback control architecture and the bacterial chemotaxis network. |
| title_sort | feedback control architecture and the bacterial chemotaxis network |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001130&type=printable |
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