HLA-DRB1 allele distribution in Chilean population: insights into rheumatoid arthritis susceptibility and protection

HLA-DRB1 allele distribution in Chilean population: insights into rheumatoid arthritis susceptibility and protection

IntroductionRheumatoid arthritis (RA) is an autoimmune disease influenced by genetic factors, particularly HLA-DRB1 alleles. The objective of this study was to characterize the distribution of HLA-DRB1 alleles in Chilean RA patients and healthy controls (HC) and evaluate associations with susceptibi...

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Main Authors: Diego Catalán, Lilian Soto, Óscar Neira, María C. Cuéllar-Gutiérrez, Roberto Díaz-Peña, Octavio Aravena, Eduard Palou, Montserrat Carrascal, Juan C. Aguillón, Jaxaira Maggi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
HLA-DRB1 alleles
shared epitope
anti-CCP antibodies
Chilean cohort
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1594723/full
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