Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography
<b>Background:</b> Atherosclerosis and its sequels, such as coronary artery disease and cerebrovascular stroke, still represent global health burdens. The pathogenesis of atherosclerosis consists of growing calcified plaques in the arterial wall and is accompanied by inflammatory process...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/22/2486 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850144929424080896 |
|---|---|
| author | German Rubinstein Harun Ilhan Peter Bartenstein Sebastian Lehner Marcus Hacker Andrei Todica Mathias Johannes Zacherl Maximilian Fischer |
| author_facet | German Rubinstein Harun Ilhan Peter Bartenstein Sebastian Lehner Marcus Hacker Andrei Todica Mathias Johannes Zacherl Maximilian Fischer |
| author_sort | German Rubinstein |
| collection | DOAJ |
| description | <b>Background:</b> Atherosclerosis and its sequels, such as coronary artery disease and cerebrovascular stroke, still represent global health burdens. The pathogenesis of atherosclerosis consists of growing calcified plaques in the arterial wall and is accompanied by inflammatory processes, which are not entirely understood. This study aims to evaluate the effect of peptide receptor radionuclide therapy (PRRT) using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE on atherosclerotic plaque inflammation. <b>Methods</b>: Atherosclerotic plaques in 57 cancer patients receiving PRRT using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE were longitudinally monitored by <sup>68</sup>Ga-DOTATATE PET/CT. The target-to-background ratio (TBR) and overall vessel uptake (OVU) were measured in eight distinct arterial regions (ascending aorta, aortic arch, descending aorta, abdominal aorta, both iliac arteries, and both carotid arteries) to monitor calcified plaques. <b>Results:</b> PET/CT analysis shows a positive correlation between calcified plaque scores and the <sup>68</sup>Ga-DOTATATE overall vessel uptake (OVU) in cancer patients. After PRRT, an initially high OVU was observed to decrease in the therapy group compared to the control group. An excellent correlation could be shown for each target-to-background ratio (TBR) to the OVU, especially the ascending aorta. <b>Conclusions:</b> The ascending aorta could present a future reference for estimating generalized atherosclerotic inflammatory processes. PRRT might represent a therapeutic approach to modulating atherosclerotic plaques. |
| format | Article |
| id | doaj-art-0992d8df72e94d2d9cfc8b480d5ab93e |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-0992d8df72e94d2d9cfc8b480d5ab93e2025-08-20T02:28:12ZengMDPI AGDiagnostics2075-44182024-11-011422248610.3390/diagnostics14222486Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer TomographyGerman Rubinstein0Harun Ilhan1Peter Bartenstein2Sebastian Lehner3Marcus Hacker4Andrei Todica5Mathias Johannes Zacherl6Maximilian Fischer7Department of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, GermanyDivision of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, 81377 Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Germany<b>Background:</b> Atherosclerosis and its sequels, such as coronary artery disease and cerebrovascular stroke, still represent global health burdens. The pathogenesis of atherosclerosis consists of growing calcified plaques in the arterial wall and is accompanied by inflammatory processes, which are not entirely understood. This study aims to evaluate the effect of peptide receptor radionuclide therapy (PRRT) using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE on atherosclerotic plaque inflammation. <b>Methods</b>: Atherosclerotic plaques in 57 cancer patients receiving PRRT using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE were longitudinally monitored by <sup>68</sup>Ga-DOTATATE PET/CT. The target-to-background ratio (TBR) and overall vessel uptake (OVU) were measured in eight distinct arterial regions (ascending aorta, aortic arch, descending aorta, abdominal aorta, both iliac arteries, and both carotid arteries) to monitor calcified plaques. <b>Results:</b> PET/CT analysis shows a positive correlation between calcified plaque scores and the <sup>68</sup>Ga-DOTATATE overall vessel uptake (OVU) in cancer patients. After PRRT, an initially high OVU was observed to decrease in the therapy group compared to the control group. An excellent correlation could be shown for each target-to-background ratio (TBR) to the OVU, especially the ascending aorta. <b>Conclusions:</b> The ascending aorta could present a future reference for estimating generalized atherosclerotic inflammatory processes. PRRT might represent a therapeutic approach to modulating atherosclerotic plaques.https://www.mdpi.com/2075-4418/14/22/2486atherosclerosisplaque imagingDOTATATEPET/CTinflammation |
| spellingShingle | German Rubinstein Harun Ilhan Peter Bartenstein Sebastian Lehner Marcus Hacker Andrei Todica Mathias Johannes Zacherl Maximilian Fischer Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography Diagnostics atherosclerosis plaque imaging DOTATATE PET/CT inflammation |
| title | Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography |
| title_full | Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography |
| title_fullStr | Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography |
| title_full_unstemmed | Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography |
| title_short | Peptide Receptor Radionuclide Therapy Using <sup>90</sup>Y- and <sup>177</sup>Lu-DOTATATE Modulating Atherosclerotic Plaque Inflammation: Longitudinal Monitoring by <sup>68</sup>Ga-DOTATATE Positron Emissions Tomography/Computer Tomography |
| title_sort | peptide receptor radionuclide therapy using sup 90 sup y and sup 177 sup lu dotatate modulating atherosclerotic plaque inflammation longitudinal monitoring by sup 68 sup ga dotatate positron emissions tomography computer tomography |
| topic | atherosclerosis plaque imaging DOTATATE PET/CT inflammation |
| url | https://www.mdpi.com/2075-4418/14/22/2486 |
| work_keys_str_mv | AT germanrubinstein peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT harunilhan peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT peterbartenstein peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT sebastianlehner peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT marcushacker peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT andreitodica peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT mathiasjohanneszacherl peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography AT maximilianfischer peptidereceptorradionuclidetherapyusingsup90supyandsup177supludotatatemodulatingatheroscleroticplaqueinflammationlongitudinalmonitoringbysup68supgadotatatepositronemissionstomographycomputertomography |