Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats
The present study was aimed at evaluating the cardioprotective effect of novel synthetic N′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide derivative, by estimating the various biomarkers like creatine kinase-myoglobin (CK-MB), lactate dehydrogenase (LDH), aspartate aminot...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/260672 |
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| author | Salma Tabassum Kiran Gangarapu Gouthami Thumma Sarangapani Manda Rama Narsimha Reddy Anreddy |
| author_facet | Salma Tabassum Kiran Gangarapu Gouthami Thumma Sarangapani Manda Rama Narsimha Reddy Anreddy |
| author_sort | Salma Tabassum |
| collection | DOAJ |
| description | The present study was aimed at evaluating the cardioprotective effect of novel synthetic N′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide derivative, by estimating the various biomarkers like creatine kinase-myoglobin (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and triglycerides (TG) in plasma and antioxidants like catalase, superoxide dismutase in heart tissue homogenate, and histopathological examination of heart tissues. The results showed the significant (P<0.05) dose dependent decrease in elevated cardiotoxic biomarkers CK-MB, LDH, AST, and TG levels. The histopathological studies of heart tissues showed mild degeneration of muscle bundles and less interstitial edematous changes. The results showed the significant (P<0.05) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates. These observations enable us to conclude that N′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide has cardioprotective activity against doxorubicin induced cardiotoxicity. |
| format | Article |
| id | doaj-art-0991733a3fc14760ba903493ca6b41c7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-0991733a3fc14760ba903493ca6b41c72025-02-03T01:00:24ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/260672260672Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in RatsSalma Tabassum0Kiran Gangarapu1Gouthami Thumma2Sarangapani Manda3Rama Narsimha Reddy Anreddy4Department of Pharmacology, Vaageswari College of Pharmacy, Rama Krishna Colony, Beside LMD Police Station, Karimnagar, Andhra Pradesh 505 481, IndiaDepartment of Pharmaceutical Chemistry, Kakatiya Institute of Pharmaceutical Sciences, Pembarthy, Hasanparthy, Warangal 506 371, IndiaDeparment of Pharmaceutics, SVS School of Pharmacy, SVS group of Institutions, Ramaram, Hanamkonda, Warangal 506 015, IndiaDepartment of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, IndiaDepartment of Pharmacology, Vaageswari College of Pharmacy, Rama Krishna Colony, Beside LMD Police Station, Karimnagar, Andhra Pradesh 505 481, IndiaThe present study was aimed at evaluating the cardioprotective effect of novel synthetic N′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide derivative, by estimating the various biomarkers like creatine kinase-myoglobin (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and triglycerides (TG) in plasma and antioxidants like catalase, superoxide dismutase in heart tissue homogenate, and histopathological examination of heart tissues. The results showed the significant (P<0.05) dose dependent decrease in elevated cardiotoxic biomarkers CK-MB, LDH, AST, and TG levels. The histopathological studies of heart tissues showed mild degeneration of muscle bundles and less interstitial edematous changes. The results showed the significant (P<0.05) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates. These observations enable us to conclude that N′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide has cardioprotective activity against doxorubicin induced cardiotoxicity.http://dx.doi.org/10.1155/2014/260672 |
| spellingShingle | Salma Tabassum Kiran Gangarapu Gouthami Thumma Sarangapani Manda Rama Narsimha Reddy Anreddy Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats Journal of Chemistry |
| title | Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats |
| title_full | Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats |
| title_fullStr | Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats |
| title_full_unstemmed | Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats |
| title_short | Cardioprotective Activity of N′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats |
| title_sort | cardioprotective activity of n n bis 5 methyl 2 oxo 1 2 dihydro 3h indol 3 ylidene carbonohydrazide derivative against doxorubicin induced cardiotoxicity in rats |
| url | http://dx.doi.org/10.1155/2014/260672 |
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