Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations
Sepsis, a severe global health challenge characterized by life-threatening organ dysfunction stemming from a dysregulated immune response to drug-resistant pathogens, imposes a substantial disease burden. The intricate nature of sepsis necessitates meticulous drug administration and underscores the...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Pharmaceutical Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277321692500025X |
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| author | Xinxin Wang Xuemei Wang Yuxin Cao Wenming Wang Dandan Liu Jingwen Zhang Yuxiu Chen Daquan Chen |
| author_facet | Xinxin Wang Xuemei Wang Yuxin Cao Wenming Wang Dandan Liu Jingwen Zhang Yuxiu Chen Daquan Chen |
| author_sort | Xinxin Wang |
| collection | DOAJ |
| description | Sepsis, a severe global health challenge characterized by life-threatening organ dysfunction stemming from a dysregulated immune response to drug-resistant pathogens, imposes a substantial disease burden. The intricate nature of sepsis necessitates meticulous drug administration and underscores the urgency for advanced drug delivery strategies. This paper presents a comprehensive overview of recent advancements in nanotechnology-driven therapeutic interventions for sepsis, emphasizing innovative approaches such as stimulus-responsive and nano-drug delivery systems that have been applied to tackle sepsis and its associated complications. Drawing from various theories and mechanistic insights into sepsis pathogenesis, we explore novel therapeutic avenues and their potential integration with nano-delivery systems, considering factors such as the microenvironment. We demonstrate how these nano-delivery systems can enhance treatment accuracy and diversity. Furthermore, the synergy between nanomedicine and emerging technologies like CRISPR, CAR-T therapy, AI, microfluidics, microbiome research, and immunotherapy holds the promise to revolutionize sepsis diagnosis, treatment, and management strategies. However, overcoming pathogen resistance, precisely modulating excessive immune response/immunosuppression, and achieving efficient targeted delivery of nanocarriers in complex pathological environments remain core challenges. Future research needs to focus on the development of smarter and more responsive nanoplatforms and deeply explore their deep integration with multiple cutting-edge technologies in order to advance the clinical translation of precision sepsis diagnosis and treatment. |
| format | Article |
| id | doaj-art-098fa30495bf4635aef4a252ffbc0174 |
| institution | DOAJ |
| issn | 2773-2169 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmaceutical Science Advances |
| spelling | doaj-art-098fa30495bf4635aef4a252ffbc01742025-08-20T03:05:49ZengElsevierPharmaceutical Science Advances2773-21692025-12-01310008710.1016/j.pscia.2025.100087Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizationsXinxin Wang0Xuemei Wang1Yuxin Cao2Wenming Wang3Dandan Liu4Jingwen Zhang5Yuxiu Chen6Daquan Chen7School of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR ChinaSchool of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR ChinaSchool of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR ChinaSchool of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR ChinaSchool of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR ChinaSchool of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR ChinaShandong University of Traditional Chinese Medicine, Jinan, 250355, PR ChinaSchool of Pharmacy, Yantai University, 30# Qingquan Road, Yantai, 264005, PR China; Corresponding author. Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs, School of Pharmacy, Yantai University, Yantai, 264005, PR China.Sepsis, a severe global health challenge characterized by life-threatening organ dysfunction stemming from a dysregulated immune response to drug-resistant pathogens, imposes a substantial disease burden. The intricate nature of sepsis necessitates meticulous drug administration and underscores the urgency for advanced drug delivery strategies. This paper presents a comprehensive overview of recent advancements in nanotechnology-driven therapeutic interventions for sepsis, emphasizing innovative approaches such as stimulus-responsive and nano-drug delivery systems that have been applied to tackle sepsis and its associated complications. Drawing from various theories and mechanistic insights into sepsis pathogenesis, we explore novel therapeutic avenues and their potential integration with nano-delivery systems, considering factors such as the microenvironment. We demonstrate how these nano-delivery systems can enhance treatment accuracy and diversity. Furthermore, the synergy between nanomedicine and emerging technologies like CRISPR, CAR-T therapy, AI, microfluidics, microbiome research, and immunotherapy holds the promise to revolutionize sepsis diagnosis, treatment, and management strategies. However, overcoming pathogen resistance, precisely modulating excessive immune response/immunosuppression, and achieving efficient targeted delivery of nanocarriers in complex pathological environments remain core challenges. Future research needs to focus on the development of smarter and more responsive nanoplatforms and deeply explore their deep integration with multiple cutting-edge technologies in order to advance the clinical translation of precision sepsis diagnosis and treatment.http://www.sciencedirect.com/science/article/pii/S277321692500025XSepsisNanomedicineDrug deliveryMicrobiomeImmunotherapy |
| spellingShingle | Xinxin Wang Xuemei Wang Yuxin Cao Wenming Wang Dandan Liu Jingwen Zhang Yuxiu Chen Daquan Chen Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations Pharmaceutical Science Advances Sepsis Nanomedicine Drug delivery Microbiome Immunotherapy |
| title | Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations |
| title_full | Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations |
| title_fullStr | Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations |
| title_full_unstemmed | Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations |
| title_short | Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations |
| title_sort | nanoplatforms in sepsis storm multimodal synergy for precision immunomodulation and pathogen neutralizations |
| topic | Sepsis Nanomedicine Drug delivery Microbiome Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S277321692500025X |
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