Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study
Introduction. The relationship between serum uric acid (SUA) level and ischemic heart disease abides controversial and still has not been established as a cardiovascular risk factor. The cooperative interaction between those two factors is not fully understood. Prior epidemiological evidences of th...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2021-03-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/459/261 |
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| author | Diding Heri Prasetyo Sally Aman Nasution Idrus Alwi Murdani Abdullah |
| author_facet | Diding Heri Prasetyo Sally Aman Nasution Idrus Alwi Murdani Abdullah |
| author_sort | Diding Heri Prasetyo |
| collection | DOAJ |
| description | Introduction. The relationship between serum uric acid (SUA) level and ischemic heart disease abides controversial and still has not been established as a cardiovascular risk factor. The cooperative interaction between those two factors is not fully understood. Prior epidemiological evidences of the causal relationship is still argumentative. There were various studies using the same methods yet the outcome were different. This study aims to conduct a meta-analysis to synthesize the results of recent studies in order to obtain data quantitatively and also accurately.
Methods. This study protocol was registered with PROSPERO (CRD42020210948), and conducted according to PRISMA guidelines, tracing studies published in vulnerable periods from January 2010 to May 2020. The Cochrane Library, EBSCO, Medline/PubMed, ProQuest and Science Direct are sources of published studies. Meta-analysis was conducted to synthesize the associations between SUA level and severity of coronary artery stenosis, using random effect model to account for possible study heterogeneity. Heterogeneity was assessed using I2, and the meta-analysis was performed using Comprehensive Meta-Analysis Version 3 (CMA3) software.
Results. Five studies (n = 601 patients) identified a correlation between serum uric acid levels and Gensini scores (r = 0.548; p <0.001) in ACS patients. Heterogeneity bias was found in the analysis, whereas publication bias was not found. There was a moderate positive correlation between serum uric acid levels and the severity of coronary artery stenosis, with a correlation coefficient of 0.548 (p value <0.001).
Conclusion. The severity of coronary artery stenosis in patients with ACS is positively correlated with serum uric acid levels. |
| format | Article |
| id | doaj-art-098876c3656345bb8bdea8a1bb65d930 |
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| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2021-03-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-098876c3656345bb8bdea8a1bb65d9302025-08-20T02:01:09ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212021-03-01811016http://dx.doi.org/10.7454/jpdi.v8i1.459Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis StudyDiding Heri Prasetyo0Sally Aman Nasution1Idrus Alwi2Murdani Abdullah3Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta IndonesiaDivisi Kardiologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta Indonesia Divisi Kardiologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta Indonesia Unit Epidemiologi Klinik, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta Indonesia Introduction. The relationship between serum uric acid (SUA) level and ischemic heart disease abides controversial and still has not been established as a cardiovascular risk factor. The cooperative interaction between those two factors is not fully understood. Prior epidemiological evidences of the causal relationship is still argumentative. There were various studies using the same methods yet the outcome were different. This study aims to conduct a meta-analysis to synthesize the results of recent studies in order to obtain data quantitatively and also accurately. Methods. This study protocol was registered with PROSPERO (CRD42020210948), and conducted according to PRISMA guidelines, tracing studies published in vulnerable periods from January 2010 to May 2020. The Cochrane Library, EBSCO, Medline/PubMed, ProQuest and Science Direct are sources of published studies. Meta-analysis was conducted to synthesize the associations between SUA level and severity of coronary artery stenosis, using random effect model to account for possible study heterogeneity. Heterogeneity was assessed using I2, and the meta-analysis was performed using Comprehensive Meta-Analysis Version 3 (CMA3) software. Results. Five studies (n = 601 patients) identified a correlation between serum uric acid levels and Gensini scores (r = 0.548; p <0.001) in ACS patients. Heterogeneity bias was found in the analysis, whereas publication bias was not found. There was a moderate positive correlation between serum uric acid levels and the severity of coronary artery stenosis, with a correlation coefficient of 0.548 (p value <0.001). Conclusion. The severity of coronary artery stenosis in patients with ACS is positively correlated with serum uric acid levels.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/459/261acute coronary syndromesgensini scoreuric acid |
| spellingShingle | Diding Heri Prasetyo Sally Aman Nasution Idrus Alwi Murdani Abdullah Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study Jurnal Penyakit Dalam Indonesia acute coronary syndromes gensini score uric acid |
| title | Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study |
| title_full | Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study |
| title_fullStr | Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study |
| title_full_unstemmed | Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study |
| title_short | Correlation of Serum Uric Acid Levels with The Severity Of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome: Meta Analysis Study |
| title_sort | correlation of serum uric acid levels with the severity of coronary artery stenosis in patients with acute coronary syndrome meta analysis study |
| topic | acute coronary syndromes gensini score uric acid |
| url | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/459/261 |
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