Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
Recent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,...
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Public Library of Science (PLoS)
2009-04-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000445&type=printable |
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| author | Nicole Soranzo Fernando Rivadeneira Usha Chinappen-Horsley Ida Malkina J Brent Richards Naomi Hammond Lisette Stolk Alexandra Nica Michael Inouye Albert Hofman Jonathan Stephens Eleanor Wheeler Pascal Arp Rhian Gwilliam P Mila Jhamai Simon Potter Amy Chaney Mohammed J R Ghori Radhi Ravindrarajah Sergey Ermakov Karol Estrada Huibert A P Pols Frances M Williams Wendy L McArdle Joyce B van Meurs Ruth J F Loos Emmanouil T Dermitzakis Kourosh R Ahmadi Deborah J Hart Willem H Ouwehand Nicholas J Wareham Inês Barroso Manjinder S Sandhu David P Strachan Gregory Livshits Timothy D Spector André G Uitterlinden Panos Deloukas |
| author_facet | Nicole Soranzo Fernando Rivadeneira Usha Chinappen-Horsley Ida Malkina J Brent Richards Naomi Hammond Lisette Stolk Alexandra Nica Michael Inouye Albert Hofman Jonathan Stephens Eleanor Wheeler Pascal Arp Rhian Gwilliam P Mila Jhamai Simon Potter Amy Chaney Mohammed J R Ghori Radhi Ravindrarajah Sergey Ermakov Karol Estrada Huibert A P Pols Frances M Williams Wendy L McArdle Joyce B van Meurs Ruth J F Loos Emmanouil T Dermitzakis Kourosh R Ahmadi Deborah J Hart Willem H Ouwehand Nicholas J Wareham Inês Barroso Manjinder S Sandhu David P Strachan Gregory Livshits Timothy D Spector André G Uitterlinden Panos Deloukas |
| author_sort | Nicole Soranzo |
| collection | DOAJ |
| description | Recent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,187 individuals, and identified 17 genomic regions with GW-significant association with height. Of these, two are entirely novel (rs11809207 in CATSPER4, combined P-value = 6.1x10(-8) and rs910316 in TMED10, P-value = 1.4x10(-7)) and two had previously been described with weak statistical support (rs10472828 in NPR3, P-value = 3x10(-7) and rs849141 in JAZF1, P-value = 3.2x10(-11)). One locus (rs1182188 at GNA12) identifies the first height eQTL. We also assessed the contribution of height loci to the upper- (trunk) and lower-body (hip axis and femur) skeletal components of height. We find evidence for several loci associated with trunk length (including rs6570507 in GPR126, P-value = 4x10(-5) and rs6817306 in LCORL, P-value = 4x10(-4)), hip axis length (including rs6830062 at LCORL, P-value = 4.8x10(-4) and rs4911494 at UQCC, P-value = 1.9x10(-4)), and femur length (including rs710841 at PRKG2, P-value = 2.4x10(-5) and rs10946808 at HIST1H1D, P-value = 6.4x10(-6)). Finally, we used conditional analyses to explore a possible differential contribution of the height loci to these different skeletal size measurements. In addition to validating four novel loci controlling adult stature, our study represents the first effort to assess the contribution of genetic loci to three skeletal components of height. Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height. |
| format | Article |
| id | doaj-art-09883929ce8d47f5a57ac041ec00d375 |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2009-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-09883929ce8d47f5a57ac041ec00d3752025-08-20T02:17:24ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-04-0154e100044510.1371/journal.pgen.1000445Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.Nicole SoranzoFernando RivadeneiraUsha Chinappen-HorsleyIda MalkinaJ Brent RichardsNaomi HammondLisette StolkAlexandra NicaMichael InouyeAlbert HofmanJonathan StephensEleanor WheelerPascal ArpRhian GwilliamP Mila JhamaiSimon PotterAmy ChaneyMohammed J R GhoriRadhi RavindrarajahSergey ErmakovKarol EstradaHuibert A P PolsFrances M WilliamsWendy L McArdleJoyce B van MeursRuth J F LoosEmmanouil T DermitzakisKourosh R AhmadiDeborah J HartWillem H OuwehandNicholas J WarehamInês BarrosoManjinder S SandhuDavid P StrachanGregory LivshitsTimothy D SpectorAndré G UitterlindenPanos DeloukasRecent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,187 individuals, and identified 17 genomic regions with GW-significant association with height. Of these, two are entirely novel (rs11809207 in CATSPER4, combined P-value = 6.1x10(-8) and rs910316 in TMED10, P-value = 1.4x10(-7)) and two had previously been described with weak statistical support (rs10472828 in NPR3, P-value = 3x10(-7) and rs849141 in JAZF1, P-value = 3.2x10(-11)). One locus (rs1182188 at GNA12) identifies the first height eQTL. We also assessed the contribution of height loci to the upper- (trunk) and lower-body (hip axis and femur) skeletal components of height. We find evidence for several loci associated with trunk length (including rs6570507 in GPR126, P-value = 4x10(-5) and rs6817306 in LCORL, P-value = 4x10(-4)), hip axis length (including rs6830062 at LCORL, P-value = 4.8x10(-4) and rs4911494 at UQCC, P-value = 1.9x10(-4)), and femur length (including rs710841 at PRKG2, P-value = 2.4x10(-5) and rs10946808 at HIST1H1D, P-value = 6.4x10(-6)). Finally, we used conditional analyses to explore a possible differential contribution of the height loci to these different skeletal size measurements. In addition to validating four novel loci controlling adult stature, our study represents the first effort to assess the contribution of genetic loci to three skeletal components of height. Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000445&type=printable |
| spellingShingle | Nicole Soranzo Fernando Rivadeneira Usha Chinappen-Horsley Ida Malkina J Brent Richards Naomi Hammond Lisette Stolk Alexandra Nica Michael Inouye Albert Hofman Jonathan Stephens Eleanor Wheeler Pascal Arp Rhian Gwilliam P Mila Jhamai Simon Potter Amy Chaney Mohammed J R Ghori Radhi Ravindrarajah Sergey Ermakov Karol Estrada Huibert A P Pols Frances M Williams Wendy L McArdle Joyce B van Meurs Ruth J F Loos Emmanouil T Dermitzakis Kourosh R Ahmadi Deborah J Hart Willem H Ouwehand Nicholas J Wareham Inês Barroso Manjinder S Sandhu David P Strachan Gregory Livshits Timothy D Spector André G Uitterlinden Panos Deloukas Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genetics |
| title | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. |
| title_full | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. |
| title_fullStr | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. |
| title_full_unstemmed | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. |
| title_short | Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. |
| title_sort | meta analysis of genome wide scans for human adult stature identifies novel loci and associations with measures of skeletal frame size |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000445&type=printable |
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