Breast Cancer‐Derived Extracellular Vesicles Modulate the Cytoplasmic and Cytoskeletal Dynamics of Blood‐Brain Barrier Endothelial Cells

Breast Cancer‐Derived Extracellular Vesicles Modulate the Cytoplasmic and Cytoskeletal Dynamics of Blood‐Brain Barrier Endothelial Cells

ABSTRACT Extracellular vesicles (EVs) from brain‐seeking breast cancer cells (Br‐EVs) breach the blood‐brain barrier (BBB) via transcytosis and promote brain metastasis. Here, we defined the mechanisms by which Br‐EVs modulate brain endothelial cell (BEC) dynamics to facilitate their BBB transcytosi...

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Bibliographic Details
Main Authors:	Sara Busatto, Tzu‐Hsi Song, Hyung Joon Kim, Caleb Hallinan, Michael N. Lombardo, Anat O. Stemmer‐Rachamimov, Kwonmoo Lee, Marsha A. Moses
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	Journal of Extracellular Vesicles
Subjects:	blood‐brain barrier brain metastasis breast cancer exosomes extracellular vesicles microvesicles
Online Access:	https://doi.org/10.1002/jev2.70038
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