Transcriptomic landscape of Hras12V oncogene-induced hepatocarcinogenesis with gender disparity

Transcriptomic landscape of Hras12V oncogene-induced hepatocarcinogenesis with gender disparity

Abstract The genesis of hepatocellular carcinoma (HCC) is closely related to male factors and hyper-activated Ras signals. A transcriptomic database was established via RNA-Seq of HCC (T) and the adjacent precancerous liver tissue (P) of Hras12V transgenic mice (Ras-Tg, HCC model) and the normal liv...

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Bibliographic Details
Main Authors: Huaiyuan Di, Zhuona Rong, Nan Mao, Huiling Li, Jun Chen, Renwu Liu, Aiguo Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Transcriptome
Ras oncogene
Sex disparity
Online Access:https://doi.org/10.1186/s12885-025-13476-7
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