Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance

Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance

Abstract Lipid droplet-associated hydrolase (LDAH) is a lipid hydrolase abundantly expressed in adipose and ovarian tissues and macrophages. However, LDAH’s functions in ovarian cancer are largely unknown. Analysis of publicly available patient datasets showed decreased LDAH expression in advanced s...

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Main Authors: Bhawna Deswal, Sameera Nallanthighal, Elahe Nikpayam, Zenab Minhas, Antoni Paul, Young-Hwa Goo, Dong-Joo Cheon
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-025-00566-1
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