Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury
Abstract Acute lung injury (ALI) is a clinically critical disease characterized by overwhelming inflammatory response and significant tissue damage with no specific treatment available currently. As a key player in the pathogenesis of ALI, macrophages are aberrantly activated and polarize toward the...
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202416594 |
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| author | Xin Shou Changjiang Chen Hangjie Ying Zhiyun Liu Lingyao Zeng Qiujie Li Lanjie Lei Bingyong Mao Wei Zhang Shumao Cui Liyun Shi |
| author_facet | Xin Shou Changjiang Chen Hangjie Ying Zhiyun Liu Lingyao Zeng Qiujie Li Lanjie Lei Bingyong Mao Wei Zhang Shumao Cui Liyun Shi |
| author_sort | Xin Shou |
| collection | DOAJ |
| description | Abstract Acute lung injury (ALI) is a clinically critical disease characterized by overwhelming inflammatory response and significant tissue damage with no specific treatment available currently. As a key player in the pathogenesis of ALI, macrophages are aberrantly activated and polarize toward the pro‐inflammatory phenotypes, leading to overzealous inflammation and lung injury. Mitochondria is recognized as a crucial signaling hub governing macrophage function and polarization, deregulation of which is causatively related with defective metabolism of macrophages, deregulated inflammation, and hence ALI. Herein, an inflammation‐responsive, biomimetic metal‐organic framework (MOF) nanoplatform, termed a127/mito@ZIF@Ma is developed, which is sophistically designed for synergistic delivery of macrophage‐derived mitochondria and anti‐inflammatory miRNA‐127 antagonist to resume pulmonary macrophages homeostasis and alleviate lung inflammation and injury. Notably, macrophage membrane encapsulation conferred the biomimetic MOF with enhanced transport efficacy both in vitro and in vivo. Therefore, the administration of the nanoparticles accordingly conferred a profound protection of mice against lung inflammation and injury induced by either bacterial or viral infection with unnoticeable tissue toxicity. The study thus devises a novel MOF‐based nanosystem that integrates mitochondria transplantation and miRNA therapeutics, which may open a new avenue for treating ALI and relevant critical diseases. |
| format | Article |
| id | doaj-art-0975695bf41f4bc8b2aae1fb4ee7f28d |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-0975695bf41f4bc8b2aae1fb4ee7f28d2025-08-20T02:24:50ZengWileyAdvanced Science2198-38442025-04-011216n/an/a10.1002/advs.202416594Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung InjuryXin Shou0Changjiang Chen1Hangjie Ying2Zhiyun Liu3Lingyao Zeng4Qiujie Li5Lanjie Lei6Bingyong Mao7Wei Zhang8Shumao Cui9Liyun Shi10Key lab of Artificial Organs and Computational Medicine Institute of Translational Medicine Zhejiang Shuren University Hangzhou Zhejiang 310015 ChinaDepartment of Immunology Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 ChinaDepartment of Experiment Center Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou Zhejiang 310022 ChinaKey lab of Artificial Organs and Computational Medicine Institute of Translational Medicine Zhejiang Shuren University Hangzhou Zhejiang 310015 ChinaKey lab of Artificial Organs and Computational Medicine Institute of Translational Medicine Zhejiang Shuren University Hangzhou Zhejiang 310015 ChinaKey lab of Artificial Organs and Computational Medicine Institute of Translational Medicine Zhejiang Shuren University Hangzhou Zhejiang 310015 ChinaKey lab of Artificial Organs and Computational Medicine Institute of Translational Medicine Zhejiang Shuren University Hangzhou Zhejiang 310015 ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu 214122 ChinaDepartment of Immunology Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu 214122 ChinaKey lab of Artificial Organs and Computational Medicine Institute of Translational Medicine Zhejiang Shuren University Hangzhou Zhejiang 310015 ChinaAbstract Acute lung injury (ALI) is a clinically critical disease characterized by overwhelming inflammatory response and significant tissue damage with no specific treatment available currently. As a key player in the pathogenesis of ALI, macrophages are aberrantly activated and polarize toward the pro‐inflammatory phenotypes, leading to overzealous inflammation and lung injury. Mitochondria is recognized as a crucial signaling hub governing macrophage function and polarization, deregulation of which is causatively related with defective metabolism of macrophages, deregulated inflammation, and hence ALI. Herein, an inflammation‐responsive, biomimetic metal‐organic framework (MOF) nanoplatform, termed a127/mito@ZIF@Ma is developed, which is sophistically designed for synergistic delivery of macrophage‐derived mitochondria and anti‐inflammatory miRNA‐127 antagonist to resume pulmonary macrophages homeostasis and alleviate lung inflammation and injury. Notably, macrophage membrane encapsulation conferred the biomimetic MOF with enhanced transport efficacy both in vitro and in vivo. Therefore, the administration of the nanoparticles accordingly conferred a profound protection of mice against lung inflammation and injury induced by either bacterial or viral infection with unnoticeable tissue toxicity. The study thus devises a novel MOF‐based nanosystem that integrates mitochondria transplantation and miRNA therapeutics, which may open a new avenue for treating ALI and relevant critical diseases.https://doi.org/10.1002/advs.202416594acute lung injuryinflammationmacrophagemiRNAMOF nanocarrier |
| spellingShingle | Xin Shou Changjiang Chen Hangjie Ying Zhiyun Liu Lingyao Zeng Qiujie Li Lanjie Lei Bingyong Mao Wei Zhang Shumao Cui Liyun Shi Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury Advanced Science acute lung injury inflammation macrophage miRNA MOF nanocarrier |
| title | Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury |
| title_full | Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury |
| title_fullStr | Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury |
| title_full_unstemmed | Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury |
| title_short | Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury |
| title_sort | biomimetic mof nanocarrier mediated synergistic delivery of mitochondria and anti inflammatory mirna to alleviate acute lung injury |
| topic | acute lung injury inflammation macrophage miRNA MOF nanocarrier |
| url | https://doi.org/10.1002/advs.202416594 |
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