Neurobiology of Major Depressive Disorder
We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/873278 |
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| author | Rosa Villanueva |
| author_facet | Rosa Villanueva |
| author_sort | Rosa Villanueva |
| collection | DOAJ |
| description | We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations. Furthermore, all of these factors modulate neurogenesis in brain regions involved in MDD, and are functionally interconnected in such a fashion that initial alteration in one of them results in abnormalities in the others. We highlight data of potential diagnostic significance and the relevance of this information to develop new therapeutic approaches. Controversial issues, such as whether neurogenesis is the basis of the disease or whether it is a response induced by antidepressant treatments, are also discussed. |
| format | Article |
| id | doaj-art-09724c07b8444df891194e2a14ac7fb6 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-09724c07b8444df891194e2a14ac7fb62025-02-03T01:11:18ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/873278873278Neurobiology of Major Depressive DisorderRosa Villanueva0Servicio de Psiquiatría, Hospital Universitario La Paz, 28046 Madrid, SpainWe survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations. Furthermore, all of these factors modulate neurogenesis in brain regions involved in MDD, and are functionally interconnected in such a fashion that initial alteration in one of them results in abnormalities in the others. We highlight data of potential diagnostic significance and the relevance of this information to develop new therapeutic approaches. Controversial issues, such as whether neurogenesis is the basis of the disease or whether it is a response induced by antidepressant treatments, are also discussed.http://dx.doi.org/10.1155/2013/873278 |
| spellingShingle | Rosa Villanueva Neurobiology of Major Depressive Disorder Neural Plasticity |
| title | Neurobiology of Major Depressive Disorder |
| title_full | Neurobiology of Major Depressive Disorder |
| title_fullStr | Neurobiology of Major Depressive Disorder |
| title_full_unstemmed | Neurobiology of Major Depressive Disorder |
| title_short | Neurobiology of Major Depressive Disorder |
| title_sort | neurobiology of major depressive disorder |
| url | http://dx.doi.org/10.1155/2013/873278 |
| work_keys_str_mv | AT rosavillanueva neurobiologyofmajordepressivedisorder |