A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028

A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028

BackgroundNeoantigen-based vaccines show promising therapeutic potential in solid tumors such as melanoma, GBM, NSCLC, and CRC. However, clinical responses remain suboptimal in stage IV patients, due to ineffective T-cell function and high tumor burdens. To overcome these limitations, our study inve...

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Bibliographic Details
Main Authors: Yan Zhang, Ye-Fan Hu, Lingyu Ma, Yifei Wu, Dandan Chao, Xian Chen, Zhiyuan Xu, Xiaoping Su, Wei Dai, Jiandong Huang, Pingfu Fu, Feng-Ming (Spring) Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
neoantigen vaccine
radiotherapy
immunotherapy
T cell response
low-dose radiation
high-dose radiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538032/full
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