Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report
Pyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsibl...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Infectious Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772431X2500019X |
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| author | Yuanchao Xue Filipe M. Cerqueira Heather L. Stevenson Natalie Williams-Bouyer Rong Fang |
| author_facet | Yuanchao Xue Filipe M. Cerqueira Heather L. Stevenson Natalie Williams-Bouyer Rong Fang |
| author_sort | Yuanchao Xue |
| collection | DOAJ |
| description | Pyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsible for PLA are frequently culture-negative, thus complicating clinical decision-making. Here, we report a case of PLA caused by Streptococcus intermedius, as identified via DNA metagenomic sequencing of plasma. |
| format | Article |
| id | doaj-art-096b286f73c74b7099ffa680da10dc7d |
| institution | OA Journals |
| issn | 2772-431X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infectious Medicine |
| spelling | doaj-art-096b286f73c74b7099ffa680da10dc7d2025-08-20T02:35:31ZengElsevierInfectious Medicine2772-431X2025-06-014210018010.1016/j.imj.2025.100180Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case reportYuanchao Xue0Filipe M. Cerqueira1Heather L. Stevenson2Natalie Williams-Bouyer3Rong Fang4Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USADepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USADepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USADepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USACorresponding author.; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USAPyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsible for PLA are frequently culture-negative, thus complicating clinical decision-making. Here, we report a case of PLA caused by Streptococcus intermedius, as identified via DNA metagenomic sequencing of plasma.http://www.sciencedirect.com/science/article/pii/S2772431X2500019XPyogenic liver abscessStreptococcus anginosus groupNext-generation sequencing |
| spellingShingle | Yuanchao Xue Filipe M. Cerqueira Heather L. Stevenson Natalie Williams-Bouyer Rong Fang Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report Infectious Medicine Pyogenic liver abscess Streptococcus anginosus group Next-generation sequencing |
| title | Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report |
| title_full | Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report |
| title_fullStr | Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report |
| title_full_unstemmed | Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report |
| title_short | Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report |
| title_sort | culture negative liver abscess identified with plasma microbial cell free dna sequencing a case report |
| topic | Pyogenic liver abscess Streptococcus anginosus group Next-generation sequencing |
| url | http://www.sciencedirect.com/science/article/pii/S2772431X2500019X |
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