Exercise-mediated circulating metabolites for brain health
Physical exercise benefits brain health via multi-layered mechanisms, among which exercise-mediated circulating metabolites play a crucial role. These peripheral-derived factors may cross the blood-brain barrier to modulate cellular energy homeostasis, as well as the epigenetic and post-translationa...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Advanced Exercise and Health Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950273X24000699 |
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| Summary: | Physical exercise benefits brain health via multi-layered mechanisms, among which exercise-mediated circulating metabolites play a crucial role. These peripheral-derived factors may cross the blood-brain barrier to modulate cellular energy homeostasis, as well as the epigenetic and post-translational modifications in the brain. Human and rodent model studies have identified critical metabolites including lactate, ketone bodies, and kynurenine to affect brain energy supply, neuroprotection, and cognitive functions. Understanding the signaling pathways of these metabolites can promote the therapeutic potential of exercise in mitigating neurodegenerative diseases and mental disorders. This review article thus summarizes current progress of peripheral metabolites in mediating brain functions, to emphasize the importance of regular physical activity in maintaining optimal brain health through metabolic regulation. |
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| ISSN: | 2950-273X |