Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

The synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme.

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Bibliographic Details
Main Authors:	Salvador Gallardo-Alfonzo, Ana Lilia Ocampo-Néstor, Claudia Contreras-Celedón, Luis Chacón-García
Format:	Article
Language:	English
Published:	Wiley 2014-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2014/294246
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