Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor
The synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme.
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/294246 |
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| _version_ | 1832556933188419584 |
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| author | Salvador Gallardo-Alfonzo Ana Lilia Ocampo-Néstor Claudia Contreras-Celedón Luis Chacón-García |
| author_facet | Salvador Gallardo-Alfonzo Ana Lilia Ocampo-Néstor Claudia Contreras-Celedón Luis Chacón-García |
| author_sort | Salvador Gallardo-Alfonzo |
| collection | DOAJ |
| description | The synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme. |
| format | Article |
| id | doaj-art-0967e6fe4778467daf00601c6b102806 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-0967e6fe4778467daf00601c6b1028062025-02-03T05:43:56ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/294246294246Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 InhibitorSalvador Gallardo-Alfonzo0Ana Lilia Ocampo-Néstor1Claudia Contreras-Celedón2Luis Chacón-García3Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, MexicoLaboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, MexicoLaboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, MexicoLaboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, MexicoThe synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme.http://dx.doi.org/10.1155/2014/294246 |
| spellingShingle | Salvador Gallardo-Alfonzo Ana Lilia Ocampo-Néstor Claudia Contreras-Celedón Luis Chacón-García Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor Journal of Chemistry |
| title | Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor |
| title_full | Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor |
| title_fullStr | Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor |
| title_full_unstemmed | Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor |
| title_short | Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor |
| title_sort | synthesis and docking studies of the novel n 2 2 di 1h pyrrol 2 yl ethyl adamantane 1 carboxamide a potential 11β hsd1 inhibitor |
| url | http://dx.doi.org/10.1155/2014/294246 |
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