Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population
Aim: to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods: matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D...
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Interna Publishing
2014-10-01
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| Series: | Acta Medica Indonesiana |
| Online Access: | https://mail.actamedindones.org/index.php/ijim/article/view/100 |
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| author | Bintang Y.M. Sinaga Muhammad Amin Yahwardiah Siregar Sori M Sarumpaet |
| author_facet | Bintang Y.M. Sinaga Muhammad Amin Yahwardiah Siregar Sori M Sarumpaet |
| author_sort | Bintang Y.M. Sinaga |
| collection | DOAJ |
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Aim: to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods: matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results: the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45). Conclusion: in Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB.
Key words: pulmonary tuberculosis, polymorphisms, vitamin D receptor gene, Batak, Indonesia
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| format | Article |
| id | doaj-art-09662949ca7a4aec954d9fad49ada177 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-09662949ca7a4aec954d9fad49ada1772025-08-20T03:55:48ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322014-10-01464Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic PopulationBintang Y.M. Sinaga0Muhammad Amin1Yahwardiah Siregar2Sori M Sarumpaet3Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara - Adam Malik Hospital, Medan, IndonesiaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga – dr. Soetomo Hospital, Surabaya, IndonesiaDepartment of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Epidemiology, Faculty of Public Health, Universitas Sumatera Utara, Medan, Indonesia Aim: to explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Methods: matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP. Results: the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45). Conclusion: in Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB. Key words: pulmonary tuberculosis, polymorphisms, vitamin D receptor gene, Batak, Indonesia https://mail.actamedindones.org/index.php/ijim/article/view/100 |
| spellingShingle | Bintang Y.M. Sinaga Muhammad Amin Yahwardiah Siregar Sori M Sarumpaet Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population Acta Medica Indonesiana |
| title | Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population |
| title_full | Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population |
| title_fullStr | Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population |
| title_full_unstemmed | Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population |
| title_short | Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population |
| title_sort | correlation between vitamin d receptor gene foki and bsmi polymorphisms and the susceptibility to pulmonary tuberculosis in an indonesian batak ethnic population |
| url | https://mail.actamedindones.org/index.php/ijim/article/view/100 |
| work_keys_str_mv | AT bintangymsinaga correlationbetweenvitamindreceptorgenefokiandbsmipolymorphismsandthesusceptibilitytopulmonarytuberculosisinanindonesianbatakethnicpopulation AT muhammadamin correlationbetweenvitamindreceptorgenefokiandbsmipolymorphismsandthesusceptibilitytopulmonarytuberculosisinanindonesianbatakethnicpopulation AT yahwardiahsiregar correlationbetweenvitamindreceptorgenefokiandbsmipolymorphismsandthesusceptibilitytopulmonarytuberculosisinanindonesianbatakethnicpopulation AT sorimsarumpaet correlationbetweenvitamindreceptorgenefokiandbsmipolymorphismsandthesusceptibilitytopulmonarytuberculosisinanindonesianbatakethnicpopulation |