RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration

RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration (IDD) is a leading cause of spinal disorders, driven by oxidative stress-induced nucleus pulposus cell (NPC) apoptosis and extracellular matrix (ECM) degradation. Nuclear factor erythroid 2-related factor 2 (Nrf2) activators hold therapeutic promi...

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Bibliographic Details
Main Authors: Weibin Chen, Defang Li, Lihan Chen, Jichang Fei, Mengxuan Bian, Qingmin Zeng, Zengxin Jiang, Jingping Wu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Arthritis Research & Therapy
Subjects:
RTA 408
Intervertebral disc degeneration
Oxidative stress
Apoptosis
Nrf2
NF-κB
Online Access:https://doi.org/10.1186/s13075-025-03588-7
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