Left ventricular noncompaction: Clinical-echocardiographic study

Background/Aim. Left ventricular noncompaction (LVNC) is a disorder in endomyocardial morphogenesis, seen either isolated (in the absence of other cardiac anomalies) or in association with congenital heart disease and some neuromuscular diseases. Intrauterine arrest of the compaction of myocardia...

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Main Authors: Nikolić Aleksandra, Jovović Ljiljana, Tomić Slobodan, Vuković Milan
Format: Article
Language:English
Published: Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade 2012-01-01
Series:Vojnosanitetski Pregled
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Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501201032N.pdf
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author Nikolić Aleksandra
Jovović Ljiljana
Tomić Slobodan
Vuković Milan
author_facet Nikolić Aleksandra
Jovović Ljiljana
Tomić Slobodan
Vuković Milan
author_sort Nikolić Aleksandra
collection DOAJ
description Background/Aim. Left ventricular noncompaction (LVNC) is a disorder in endomyocardial morphogenesis, seen either isolated (in the absence of other cardiac anomalies) or in association with congenital heart disease and some neuromuscular diseases. Intrauterine arrest of the compaction of myocardial fibers is postulated to be the reason of LVNC. Recognition of this condition is extremely important due to its high mortality and morbidity that lead to progressive heart failure, ventricular arrhythmias and thromboembolic events. The aim of this study was to determine the prevalence and clinical presentation of LVNC among consecutive outpatients according to clinical and echocardiographyic findings. Methode. A total of 3,854 consecutive patients examined at the Institute for Cardiovascular Diseases within a period January 2006 - January 2007 were included in the study. All the patients underwent echocardiographic examination using the same equipment (Vivid 7, GE Medical System). Echocardiographic parameters and clinical presentation in patients with echocardiographic criteria for LVNC were analyzed. Results. Analyzing 3,854 consecutive outpatients, using two-dimensional Color Doppler echocardiography from January 2006 to January 2007, 12 patients met the criteria for LVNC. Seven of them were male. The mean age at diagnosis was 45 ± 15 years. Analyzing clinical manifestation of LVNC it was found that seven patients had signs of heart failure, six had arrhythmias with no embolic events. Conclusion. Our results suggest that the real prevalence of LVNC may be higher than expected. New studies have to be done to solve this problem.
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spelling doaj-art-095aadec82e64d2eaffb3f066474b8342025-08-20T03:55:29ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502012-01-01691323610.2298/VSP1201032NLeft ventricular noncompaction: Clinical-echocardiographic studyNikolić AleksandraJovović LjiljanaTomić SlobodanVuković MilanBackground/Aim. Left ventricular noncompaction (LVNC) is a disorder in endomyocardial morphogenesis, seen either isolated (in the absence of other cardiac anomalies) or in association with congenital heart disease and some neuromuscular diseases. Intrauterine arrest of the compaction of myocardial fibers is postulated to be the reason of LVNC. Recognition of this condition is extremely important due to its high mortality and morbidity that lead to progressive heart failure, ventricular arrhythmias and thromboembolic events. The aim of this study was to determine the prevalence and clinical presentation of LVNC among consecutive outpatients according to clinical and echocardiographyic findings. Methode. A total of 3,854 consecutive patients examined at the Institute for Cardiovascular Diseases within a period January 2006 - January 2007 were included in the study. All the patients underwent echocardiographic examination using the same equipment (Vivid 7, GE Medical System). Echocardiographic parameters and clinical presentation in patients with echocardiographic criteria for LVNC were analyzed. Results. Analyzing 3,854 consecutive outpatients, using two-dimensional Color Doppler echocardiography from January 2006 to January 2007, 12 patients met the criteria for LVNC. Seven of them were male. The mean age at diagnosis was 45 ± 15 years. Analyzing clinical manifestation of LVNC it was found that seven patients had signs of heart failure, six had arrhythmias with no embolic events. Conclusion. Our results suggest that the real prevalence of LVNC may be higher than expected. New studies have to be done to solve this problem.http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501201032N.pdfheart defects, congenitalventricular disfunctionechocardiographydiagnosisprevalence
spellingShingle Nikolić Aleksandra
Jovović Ljiljana
Tomić Slobodan
Vuković Milan
Left ventricular noncompaction: Clinical-echocardiographic study
Vojnosanitetski Pregled
heart defects, congenital
ventricular disfunction
echocardiography
diagnosis
prevalence
title Left ventricular noncompaction: Clinical-echocardiographic study
title_full Left ventricular noncompaction: Clinical-echocardiographic study
title_fullStr Left ventricular noncompaction: Clinical-echocardiographic study
title_full_unstemmed Left ventricular noncompaction: Clinical-echocardiographic study
title_short Left ventricular noncompaction: Clinical-echocardiographic study
title_sort left ventricular noncompaction clinical echocardiographic study
topic heart defects, congenital
ventricular disfunction
echocardiography
diagnosis
prevalence
url http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501201032N.pdf
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AT jovovicljiljana leftventricularnoncompactionclinicalechocardiographicstudy
AT tomicslobodan leftventricularnoncompactionclinicalechocardiographicstudy
AT vukovicmilan leftventricularnoncompactionclinicalechocardiographicstudy