Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement
Abstract Hereditary transthyretin amyloidosis (ATTRv, v for variant) is a genetic disorder characterized by the deposition of misfolded transthyretin (TTR) protein in tissues, resulting in progressive dysfunction of multiple organs, including the nervous system, heart, kidneys, and gastrointestinal...
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| Language: | English |
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Adis, Springer Healthcare
2025-01-01
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| Series: | Neurology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40120-024-00696-5 |
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| author | Valeria Guglielmino Francesca Vitali Angela Romano Guido Primiano Maria Ausilia Sciarrone Marco Luigetti |
| author_facet | Valeria Guglielmino Francesca Vitali Angela Romano Guido Primiano Maria Ausilia Sciarrone Marco Luigetti |
| author_sort | Valeria Guglielmino |
| collection | DOAJ |
| description | Abstract Hereditary transthyretin amyloidosis (ATTRv, v for variant) is a genetic disorder characterized by the deposition of misfolded transthyretin (TTR) protein in tissues, resulting in progressive dysfunction of multiple organs, including the nervous system, heart, kidneys, and gastrointestinal (GI) tract. Noninvasive serum biomarkers have become key tools for diagnosing and monitoring ATTRv. This review examines the role of available biomarkers for neurological, cardiac, renal, gastrointestinal, and multisystemic involvement in ATTRv. A thorough understanding of these biomarkers is essential for effective disease management and therapeutic monitoring. |
| format | Article |
| id | doaj-art-0959260e02d943048ace4a0ecf8da19a |
| institution | Kabale University |
| issn | 2193-8253 2193-6536 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Neurology and Therapy |
| spelling | doaj-art-0959260e02d943048ace4a0ecf8da19a2025-01-26T12:58:39ZengAdis, Springer HealthcareNeurology and Therapy2193-82532193-65362025-01-01141718410.1007/s40120-024-00696-5Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal InvolvementValeria Guglielmino0Francesca Vitali1Angela Romano2Guido Primiano3Maria Ausilia Sciarrone4Marco Luigetti5Department of Neuroscience, Università Cattolica del Sacro CuoreDepartment of Neuroscience, Università Cattolica del Sacro CuoreUOC Neurologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCSDepartment of Neuroscience, Università Cattolica del Sacro CuoreDepartment of Neuroscience, Università Cattolica del Sacro CuoreDepartment of Neuroscience, Università Cattolica del Sacro CuoreAbstract Hereditary transthyretin amyloidosis (ATTRv, v for variant) is a genetic disorder characterized by the deposition of misfolded transthyretin (TTR) protein in tissues, resulting in progressive dysfunction of multiple organs, including the nervous system, heart, kidneys, and gastrointestinal (GI) tract. Noninvasive serum biomarkers have become key tools for diagnosing and monitoring ATTRv. This review examines the role of available biomarkers for neurological, cardiac, renal, gastrointestinal, and multisystemic involvement in ATTRv. A thorough understanding of these biomarkers is essential for effective disease management and therapeutic monitoring.https://doi.org/10.1007/s40120-024-00696-5BiomarkersCardiac amyloidosisDisease progression monitoringEarly diagnosisMultisystemic diseaseNeurofilament light chain |
| spellingShingle | Valeria Guglielmino Francesca Vitali Angela Romano Guido Primiano Maria Ausilia Sciarrone Marco Luigetti Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement Neurology and Therapy Biomarkers Cardiac amyloidosis Disease progression monitoring Early diagnosis Multisystemic disease Neurofilament light chain |
| title | Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement |
| title_full | Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement |
| title_fullStr | Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement |
| title_full_unstemmed | Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement |
| title_short | Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement |
| title_sort | serum biomarkers in transthyretin amyloidosis an overview of neurofilaments cardiac renal and gastrointestinal involvement |
| topic | Biomarkers Cardiac amyloidosis Disease progression monitoring Early diagnosis Multisystemic disease Neurofilament light chain |
| url | https://doi.org/10.1007/s40120-024-00696-5 |
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