Invasive candidiasis among high prevalence neurological patients
Introduction: Invasive candidiasis is a severe form of infection. The incidence of invasive fungal infections has increased, due to the increasing number of patients with impaired immunity who are being treated through prolonged stay in hospital facilities. Neurological patient treatment methods su...
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The Journal of Infection in Developing Countries
2022-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15231 |
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| author | Weny Rinawati July Kumalawati Saptawati Bardosono Suzanna Immanuel Ninik Sukartini Nuri Dyah Indrasari |
| author_facet | Weny Rinawati July Kumalawati Saptawati Bardosono Suzanna Immanuel Ninik Sukartini Nuri Dyah Indrasari |
| author_sort | Weny Rinawati |
| collection | DOAJ |
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Introduction: Invasive candidiasis is a severe form of infection. The incidence of invasive fungal infections has increased, due to the increasing number of patients with impaired immunity who are being treated through prolonged stay in hospital facilities. Neurological patient treatment methods such as antimicrobials, corticosteroid, central venous catheter (CVC), total parenteral nutrition, and mechanical ventilation use are associated with common risk factors for invasive candidiasis. Our study demonstrated invasive candidiasis prevalence among neurological patients.
Methodology: A cross-sectional study was done with consecutive sampling of neurological patients who were hospitalized from January 2017 to February 2020 at the Mahar Mardjono National Brain Center Hospital East Jakarta Indonesia. Patients with sepsis, septic shock, or fever (> 38.5 °C), and who had not received antifungals before culture were enrolled in the study. Clinical specimens were obtained from blood, liquor cerebrospinal or other sterile sites, CVC, respiratory tract specimens, and urine or other non-sterile sites. Socio-demographic data, potential risk factors based on previous studies, clinical, and other tests data were obtained from medical records. Classification of invasive candidiasis was according to the Paphitou classification criteria.
Results: One hundred and two subjects met the study criteria. The prevalence of invasive candidiasis in neurological patients was 13.7%. All of the isolates were C. parapsilosis.
Conclusions: The prevalence of invasive candidiasis was high in the samples studied. The infection was associated with septic shock, tracheostomy, and duration of use of central venous catheter, ventilator, and steroids.
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| format | Article |
| id | doaj-art-0952fe8569c04ea29c7639ef18f7d26c |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-0952fe8569c04ea29c7639ef18f7d26c2025-08-20T03:48:47ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-05-01160510.3855/jidc.15231Invasive candidiasis among high prevalence neurological patientsWeny Rinawati0July Kumalawati1Saptawati Bardosono2Suzanna Immanuel3Ninik Sukartini4Nuri Dyah Indrasari5Laboratory of Clinical Pathology and Blood Bank, Mahar Mardjono National Brain Center Hospital, East Jakarta, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Clinical Nutrition, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia Introduction: Invasive candidiasis is a severe form of infection. The incidence of invasive fungal infections has increased, due to the increasing number of patients with impaired immunity who are being treated through prolonged stay in hospital facilities. Neurological patient treatment methods such as antimicrobials, corticosteroid, central venous catheter (CVC), total parenteral nutrition, and mechanical ventilation use are associated with common risk factors for invasive candidiasis. Our study demonstrated invasive candidiasis prevalence among neurological patients. Methodology: A cross-sectional study was done with consecutive sampling of neurological patients who were hospitalized from January 2017 to February 2020 at the Mahar Mardjono National Brain Center Hospital East Jakarta Indonesia. Patients with sepsis, septic shock, or fever (> 38.5 °C), and who had not received antifungals before culture were enrolled in the study. Clinical specimens were obtained from blood, liquor cerebrospinal or other sterile sites, CVC, respiratory tract specimens, and urine or other non-sterile sites. Socio-demographic data, potential risk factors based on previous studies, clinical, and other tests data were obtained from medical records. Classification of invasive candidiasis was according to the Paphitou classification criteria. Results: One hundred and two subjects met the study criteria. The prevalence of invasive candidiasis in neurological patients was 13.7%. All of the isolates were C. parapsilosis. Conclusions: The prevalence of invasive candidiasis was high in the samples studied. The infection was associated with septic shock, tracheostomy, and duration of use of central venous catheter, ventilator, and steroids. https://jidc.org/index.php/journal/article/view/15231cultureCandida spp.invasive candidiasisinvasive fungal infectionsneurological patients |
| spellingShingle | Weny Rinawati July Kumalawati Saptawati Bardosono Suzanna Immanuel Ninik Sukartini Nuri Dyah Indrasari Invasive candidiasis among high prevalence neurological patients Journal of Infection in Developing Countries culture Candida spp. invasive candidiasis invasive fungal infections neurological patients |
| title | Invasive candidiasis among high prevalence neurological patients |
| title_full | Invasive candidiasis among high prevalence neurological patients |
| title_fullStr | Invasive candidiasis among high prevalence neurological patients |
| title_full_unstemmed | Invasive candidiasis among high prevalence neurological patients |
| title_short | Invasive candidiasis among high prevalence neurological patients |
| title_sort | invasive candidiasis among high prevalence neurological patients |
| topic | culture Candida spp. invasive candidiasis invasive fungal infections neurological patients |
| url | https://jidc.org/index.php/journal/article/view/15231 |
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