Case Report: Optical genome mapping enables identification of complex balanced chromosomal rearrangements

Case Report: Optical genome mapping enables identification of complex balanced chromosomal rearrangements

IntroductionIndividuals with balanced chromosomal rearrangements are at an increased risk for infertility, recurrent miscarriages, and the birth of infants with congenital malformations. Traditional cytogenetic techniques are limited by their low resolution, whereas optical genome mapping offers enh...

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Bibliographic Details
Main Authors:	Xiaohang Hu, Jing Guo, Haiyang Sang, Jinyan Yan, Hong Chang, Ting Liu, Haixin Dong, Min Kong, Yanjun Tian, Liqing Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Genetics
Subjects:	optical genome mapping high-resolution karyotyping analysis chromosomal microarray analysis balanced reciprocal rearrangements complex chromosomal rearrangements
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1555485/full
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