The Model of PPARγ-Downregulated Signaling in Psoriasis
Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6529057 |
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| author | Vladimir Sobolev Anastasia Nesterova Anna Soboleva Evgenia Dvoriankova Anastas Piruzyan Dzerassa Mildzikhova Irina Korsunskaya Oxana Svitich |
| author_facet | Vladimir Sobolev Anastasia Nesterova Anna Soboleva Evgenia Dvoriankova Anastas Piruzyan Dzerassa Mildzikhova Irina Korsunskaya Oxana Svitich |
| author_sort | Vladimir Sobolev |
| collection | DOAJ |
| description | Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis. We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion. |
| format | Article |
| id | doaj-art-09502bf1ae5d46c0814eed39bc5b1cd9 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-09502bf1ae5d46c0814eed39bc5b1cd92025-02-03T01:20:50ZengWileyPPAR Research1687-47571687-47652020-01-01202010.1155/2020/65290576529057The Model of PPARγ-Downregulated Signaling in PsoriasisVladimir Sobolev0Anastasia Nesterova1Anna Soboleva2Evgenia Dvoriankova3Anastas Piruzyan4Dzerassa Mildzikhova5Irina Korsunskaya6Oxana Svitich7I. Mechnikov Research Institute for Vaccines and Sera RAMS, 5 Malyy Kazennyy Pereulok, 105064 Moscow, RussiaLife Science Research and Development Department, Elsevier Inc., Rockville, USACentre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, RussiaCentre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, RussiaCentre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, RussiaCentre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, RussiaCentre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, RussiaI. Mechnikov Research Institute for Vaccines and Sera RAMS, 5 Malyy Kazennyy Pereulok, 105064 Moscow, RussiaInteractions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis. We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.http://dx.doi.org/10.1155/2020/6529057 |
| spellingShingle | Vladimir Sobolev Anastasia Nesterova Anna Soboleva Evgenia Dvoriankova Anastas Piruzyan Dzerassa Mildzikhova Irina Korsunskaya Oxana Svitich The Model of PPARγ-Downregulated Signaling in Psoriasis PPAR Research |
| title | The Model of PPARγ-Downregulated Signaling in Psoriasis |
| title_full | The Model of PPARγ-Downregulated Signaling in Psoriasis |
| title_fullStr | The Model of PPARγ-Downregulated Signaling in Psoriasis |
| title_full_unstemmed | The Model of PPARγ-Downregulated Signaling in Psoriasis |
| title_short | The Model of PPARγ-Downregulated Signaling in Psoriasis |
| title_sort | model of pparγ downregulated signaling in psoriasis |
| url | http://dx.doi.org/10.1155/2020/6529057 |
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