Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia
Hip fractures significantly affect mortality and quality of life in the elderly population. Although alpha-blockers are commonly prescribed for lower urinary tract symptoms after transurethral resection of the prostate (TURP), their long-term safety regarding fracture risk remains controversial. Thi...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/15/4/641 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849714142941806592 |
|---|---|
| author | Wei-Hung Wang Yi-Ting Hung Chi Luo Wen-Tien Wu Ru-Ping Lee Ting-Kuo Yao Cheng-Huan Peng Hao-Wen Chen Jen-Hung Wang Kuang-Ting Yeh |
| author_facet | Wei-Hung Wang Yi-Ting Hung Chi Luo Wen-Tien Wu Ru-Ping Lee Ting-Kuo Yao Cheng-Huan Peng Hao-Wen Chen Jen-Hung Wang Kuang-Ting Yeh |
| author_sort | Wei-Hung Wang |
| collection | DOAJ |
| description | Hip fractures significantly affect mortality and quality of life in the elderly population. Although alpha-blockers are commonly prescribed for lower urinary tract symptoms after transurethral resection of the prostate (TURP), their long-term safety regarding fracture risk remains controversial. This study aimed to investigate whether long-term alpha-blocker use after TURP affects the risk of hip fractures requiring surgery in elderly men. This study included 6853 male patients aged ≥50 years who underwent TURP between 2000 and 2018. The alpha-blocker group (<i>n</i> = 1371) included patients who continued alpha-blocker treatment after TURP, while the control group (<i>n</i> = 5482) included those who had discontinued the medication. The primary outcome was hip fracture requiring surgical intervention. During follow-up (3.80 ± 1.64 years), hip fracture occurred in 4.2% of the alpha-blocker group versus 5.6% of controls. After adjusting for baseline characteristics and competing risk analysis, alpha-blocker use was associated with a significantly lower risk of hip fracture (<i>p</i> = 0.005). Subgroup analysis revealed particularly strong protective effects in patients with diabetes. Long-term use of alpha-blockers after TURP was associated with reduced hip fracture risk, particularly in patients with diabetes. These findings suggest the safety of continued alpha-blocker therapy after TURP in these patients. |
| format | Article |
| id | doaj-art-094ffc27da884ddd8ddd2b327e8f78ed |
| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-094ffc27da884ddd8ddd2b327e8f78ed2025-08-20T03:13:47ZengMDPI AGLife2075-17292025-04-0115464110.3390/life15040641Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate HyperplasiaWei-Hung Wang0Yi-Ting Hung1Chi Luo2Wen-Tien Wu3Ru-Ping Lee4Ting-Kuo Yao5Cheng-Huan Peng6Hao-Wen Chen7Jen-Hung Wang8Kuang-Ting Yeh9School of Medicine, Tzu Chi University, Hualien 970374, TaiwanSchool of Medicine, Tzu Chi University, Hualien 970374, TaiwanDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanSchool of Medicine, Tzu Chi University, Hualien 970374, TaiwanInstitute of Medical Sciences, Tzu Chi University, Hualien 970374, TaiwanDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanSchool of Medicine, Tzu Chi University, Hualien 970374, TaiwanDepartment of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanDepartment of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, TaiwanSchool of Medicine, Tzu Chi University, Hualien 970374, TaiwanHip fractures significantly affect mortality and quality of life in the elderly population. Although alpha-blockers are commonly prescribed for lower urinary tract symptoms after transurethral resection of the prostate (TURP), their long-term safety regarding fracture risk remains controversial. This study aimed to investigate whether long-term alpha-blocker use after TURP affects the risk of hip fractures requiring surgery in elderly men. This study included 6853 male patients aged ≥50 years who underwent TURP between 2000 and 2018. The alpha-blocker group (<i>n</i> = 1371) included patients who continued alpha-blocker treatment after TURP, while the control group (<i>n</i> = 5482) included those who had discontinued the medication. The primary outcome was hip fracture requiring surgical intervention. During follow-up (3.80 ± 1.64 years), hip fracture occurred in 4.2% of the alpha-blocker group versus 5.6% of controls. After adjusting for baseline characteristics and competing risk analysis, alpha-blocker use was associated with a significantly lower risk of hip fracture (<i>p</i> = 0.005). Subgroup analysis revealed particularly strong protective effects in patients with diabetes. Long-term use of alpha-blockers after TURP was associated with reduced hip fracture risk, particularly in patients with diabetes. These findings suggest the safety of continued alpha-blocker therapy after TURP in these patients.https://www.mdpi.com/2075-1729/15/4/641transurethral resectionhip fracturesbenign prostate hyperplasia |
| spellingShingle | Wei-Hung Wang Yi-Ting Hung Chi Luo Wen-Tien Wu Ru-Ping Lee Ting-Kuo Yao Cheng-Huan Peng Hao-Wen Chen Jen-Hung Wang Kuang-Ting Yeh Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia Life transurethral resection hip fractures benign prostate hyperplasia |
| title | Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia |
| title_full | Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia |
| title_fullStr | Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia |
| title_full_unstemmed | Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia |
| title_short | Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia |
| title_sort | continuation of selective alpha blocker after transurethral resection of the prostate is associated with a decreased risk of hip fractures in elderly patients diagnosed with benign prostate hyperplasia |
| topic | transurethral resection hip fractures benign prostate hyperplasia |
| url | https://www.mdpi.com/2075-1729/15/4/641 |
| work_keys_str_mv | AT weihungwang continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT yitinghung continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT chiluo continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT wentienwu continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT rupinglee continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT tingkuoyao continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT chenghuanpeng continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT haowenchen continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT jenhungwang continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia AT kuangtingyeh continuationofselectivealphablockeraftertransurethralresectionoftheprostateisassociatedwithadecreasedriskofhipfracturesinelderlypatientsdiagnosedwithbenignprostatehyperplasia |