Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review
Cyclosporine A (CsA) is a commonly used immunosuppressant, but its association with thrombotic microangiopathy (TMA) is rarely reported. In recent years, CsA has been used in pregnant women with autoimmune diseases or previous immune-related adverse pregnancies. Our case involves a 34-year-old femal...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X241308693 |
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| author | Su Zhang Hai-hui Zhou Zi-xing Zhong Qi-qi Wang Ping Huang Su-xiao Liu |
| author_facet | Su Zhang Hai-hui Zhou Zi-xing Zhong Qi-qi Wang Ping Huang Su-xiao Liu |
| author_sort | Su Zhang |
| collection | DOAJ |
| description | Cyclosporine A (CsA) is a commonly used immunosuppressant, but its association with thrombotic microangiopathy (TMA) is rarely reported. In recent years, CsA has been used in pregnant women with autoimmune diseases or previous immune-related adverse pregnancies. Our case involves a 34-year-old female who developed typical laboratory indicators of TMA while using CsA to improve pregnancy outcomes. After discontinuing CsA, the TMA markers gradually normalized. To our knowledge, this is the first report of CsA-induced TMA during pregnancy. We also reviewed previous case reports of CsA-induced TMA and summarized the possible mechanisms, characteristics, and risk factors, as well as methods to identify this rare adverse effect of CsA in pregnant women. |
| format | Article |
| id | doaj-art-0942832309a34c5d9ab7d53d7db84832 |
| institution | Kabale University |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-0942832309a34c5d9ab7d53d7db848322025-01-04T11:03:24ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-01-011310.1177/2050313X241308693Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature reviewSu Zhang0Hai-hui Zhou1Zi-xing Zhong2Qi-qi Wang3Ping Huang4Su-xiao Liu5Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCyclosporine A (CsA) is a commonly used immunosuppressant, but its association with thrombotic microangiopathy (TMA) is rarely reported. In recent years, CsA has been used in pregnant women with autoimmune diseases or previous immune-related adverse pregnancies. Our case involves a 34-year-old female who developed typical laboratory indicators of TMA while using CsA to improve pregnancy outcomes. After discontinuing CsA, the TMA markers gradually normalized. To our knowledge, this is the first report of CsA-induced TMA during pregnancy. We also reviewed previous case reports of CsA-induced TMA and summarized the possible mechanisms, characteristics, and risk factors, as well as methods to identify this rare adverse effect of CsA in pregnant women.https://doi.org/10.1177/2050313X241308693 |
| spellingShingle | Su Zhang Hai-hui Zhou Zi-xing Zhong Qi-qi Wang Ping Huang Su-xiao Liu Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review SAGE Open Medical Case Reports |
| title | Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review |
| title_full | Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review |
| title_fullStr | Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review |
| title_full_unstemmed | Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review |
| title_short | Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review |
| title_sort | cyclosporine induced thrombotic microangiopathy in pregnant women a case report and literature review |
| url | https://doi.org/10.1177/2050313X241308693 |
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