Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities
Abstract Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. Identifying non-motor biomarkers during this prodromal phase could predict phenocon...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01004-0 |
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| author | Mathangi Palanivel Krishna Kanta Ghosh Madhav Mallam Raghavan Bhuvanakantham Parasuraman Padmanabhan Kah-Leong Lim Balázs Gulyás |
| author_facet | Mathangi Palanivel Krishna Kanta Ghosh Madhav Mallam Raghavan Bhuvanakantham Parasuraman Padmanabhan Kah-Leong Lim Balázs Gulyás |
| author_sort | Mathangi Palanivel |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. Identifying non-motor biomarkers during this prodromal phase could predict phenoconversion and enable early interventions. This narrative review outlines key prodromal non-motor symptoms, summarizes imaging technologies for early detection, and explores their translational potential in guiding timely, neuroprotective therapies for at-risk individuals. |
| format | Article |
| id | doaj-art-094011fc4dd4403d8ffae479962f6d06 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-094011fc4dd4403d8ffae479962f6d062025-08-20T03:47:24ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-0111113010.1038/s41531-025-01004-0Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunitiesMathangi Palanivel0Krishna Kanta Ghosh1Madhav Mallam2Raghavan Bhuvanakantham3Parasuraman Padmanabhan4Kah-Leong Lim5Balázs Gulyás6Lee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityAbstract Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. Identifying non-motor biomarkers during this prodromal phase could predict phenoconversion and enable early interventions. This narrative review outlines key prodromal non-motor symptoms, summarizes imaging technologies for early detection, and explores their translational potential in guiding timely, neuroprotective therapies for at-risk individuals.https://doi.org/10.1038/s41531-025-01004-0 |
| spellingShingle | Mathangi Palanivel Krishna Kanta Ghosh Madhav Mallam Raghavan Bhuvanakantham Parasuraman Padmanabhan Kah-Leong Lim Balázs Gulyás Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities npj Parkinson's Disease |
| title | Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities |
| title_full | Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities |
| title_fullStr | Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities |
| title_full_unstemmed | Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities |
| title_short | Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities |
| title_sort | imaging advances to detect non motor prodromal markers of parkinson s disease and explore therapeutic translation opportunities |
| url | https://doi.org/10.1038/s41531-025-01004-0 |
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