Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue
Abstract Background This study aims to investigate whether indocyanine green lymphography (ICGL) facilitates the effectiveness and accuracy of current management of lingual microcystic lymphatic malformation (mLM). Methods This retrospective included patients under 18 years old with mLM of the tongu...
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BMC
2025-07-01
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| Series: | Head & Face Medicine |
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| Online Access: | https://doi.org/10.1186/s13005-025-00529-2 |
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| author | Tao Han Lijun Shi Songming Huang Weimin Shen |
| author_facet | Tao Han Lijun Shi Songming Huang Weimin Shen |
| author_sort | Tao Han |
| collection | DOAJ |
| description | Abstract Background This study aims to investigate whether indocyanine green lymphography (ICGL) facilitates the effectiveness and accuracy of current management of lingual microcystic lymphatic malformation (mLM). Methods This retrospective included patients under 18 years old with mLM of the tongue staged I or IIA, who underwent ICGL-aided surgical resection and sclerotherapy (ICGL group) or only surgical resection and sclerotherapy (non-ICGL group) between January 2019 and June 2024. The peri- and postoperative parameters of safety and feasibility were compared between two groups. Results A total of 42 patients were included, 19 of whom received ICGL-guidance and the other 23 were in non-ICGL group. The comparison of baseline data between the two groups revealed no significant difference. Compared to the non-ICGL group, the ICGL group demonstrated superior efficacy (P = 0.017) and required fewer subsequent treatment sessions (P = 0.027), but had longer operative duration (P = 0.001). No significant differences were observed in terms of postoperative complications, length of hospital-stay, and follow-up period. Conclusions ICGL was associated with improved postoperative outcomes and less subsequent treatment. This technique may provide rational guidance with promising clinical prospects for management of mLM of the tongue. Trail registration This study was retrospectively registered on clinicaltrials.gov: NCT06755905, date of registration: January 20, 2025. |
| format | Article |
| id | doaj-art-093eac66883947db9dbf30b38d83f69e |
| institution | DOAJ |
| issn | 1746-160X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | Head & Face Medicine |
| spelling | doaj-art-093eac66883947db9dbf30b38d83f69e2025-08-20T03:06:09ZengBMCHead & Face Medicine1746-160X2025-07-012111810.1186/s13005-025-00529-2Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongueTao Han0Lijun Shi1Songming Huang2Weimin Shen3Department of Burns and Plastic Surgery, Children’s Hospital of Nanjing Medical UniversityDepartment of Burns and Plastic Surgery, Children’s Hospital of Nanjing Medical UniversityDepartment of Nephrology, Children’s Hospital of Nanjing Medical UniversityDepartment of Burns and Plastic Surgery, Children’s Hospital of Nanjing Medical UniversityAbstract Background This study aims to investigate whether indocyanine green lymphography (ICGL) facilitates the effectiveness and accuracy of current management of lingual microcystic lymphatic malformation (mLM). Methods This retrospective included patients under 18 years old with mLM of the tongue staged I or IIA, who underwent ICGL-aided surgical resection and sclerotherapy (ICGL group) or only surgical resection and sclerotherapy (non-ICGL group) between January 2019 and June 2024. The peri- and postoperative parameters of safety and feasibility were compared between two groups. Results A total of 42 patients were included, 19 of whom received ICGL-guidance and the other 23 were in non-ICGL group. The comparison of baseline data between the two groups revealed no significant difference. Compared to the non-ICGL group, the ICGL group demonstrated superior efficacy (P = 0.017) and required fewer subsequent treatment sessions (P = 0.027), but had longer operative duration (P = 0.001). No significant differences were observed in terms of postoperative complications, length of hospital-stay, and follow-up period. Conclusions ICGL was associated with improved postoperative outcomes and less subsequent treatment. This technique may provide rational guidance with promising clinical prospects for management of mLM of the tongue. Trail registration This study was retrospectively registered on clinicaltrials.gov: NCT06755905, date of registration: January 20, 2025.https://doi.org/10.1186/s13005-025-00529-2Indocyanine green lymphographyMicrocystic lymphatic malformationTongueChildren |
| spellingShingle | Tao Han Lijun Shi Songming Huang Weimin Shen Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue Head & Face Medicine Indocyanine green lymphography Microcystic lymphatic malformation Tongue Children |
| title | Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue |
| title_full | Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue |
| title_fullStr | Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue |
| title_full_unstemmed | Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue |
| title_short | Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue |
| title_sort | application value of indocyanine green lymphography in the management of stage i iia microcystic lymphatic malformation of the tongue |
| topic | Indocyanine green lymphography Microcystic lymphatic malformation Tongue Children |
| url | https://doi.org/10.1186/s13005-025-00529-2 |
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