Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury
Background Sepsis-associated acute kidney injury (S-AKI) is a critical illness and is often associated with high morbidity and mortality rates. The soluble urokinase-type plasminogen activator receptor (suPAR) is an important immune mediator and is involved in kidney injury. However, its diagnostic...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2307959 |
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| author | Wenwen Zhang Yue Gu Jing Zhou Juntao Wang Xiaoru Zhao Xiaoyu Deng Han Li Lei Yan Xiaojing Jiao Fengmin Shao |
| author_facet | Wenwen Zhang Yue Gu Jing Zhou Juntao Wang Xiaoru Zhao Xiaoyu Deng Han Li Lei Yan Xiaojing Jiao Fengmin Shao |
| author_sort | Wenwen Zhang |
| collection | DOAJ |
| description | Background Sepsis-associated acute kidney injury (S-AKI) is a critical illness and is often associated with high morbidity and mortality rates. The soluble urokinase-type plasminogen activator receptor (suPAR) is an important immune mediator and is involved in kidney injury. However, its diagnostic value in S-AKI patients remains unclear. Therefore, we assessed the early predictive value of suPAR for S-AKI patients.Methods We prospectively enrolled adult patients, immediately after fulfilling the sepsis-3 criteria. Plasma suPAR levels at 0-, 12-, 24-, and 48-h post-sepsis diagnosis were measured. S-AKI development was the primary outcome. S-AKI risk factors were analyzed using logistic regression, and the value of plasma suPAR for early S-AKI diagnosis was assessed using receiver operating characteristic (ROC) curves.Results Of 179 sepsis patients, 63 (35.2%) developed AKI during hospitalization. At 12-, 24-, and 48-h post-sepsis diagnosis, plasma suPAR levels were significantly higher in patients with S-AKI than in patients without S-AKI (p < 0.05). The plasma suPAR had the highest area under the ROC curve of 0.700 (95% confidence interval (CI), 0.621–0.779) at 24-h post-sepsis diagnosis, at which the best discrimination ability for S-AKI was achieved with suPAR of ≥6.31 ng/mL (sensitivity 61.9% and specificity 71.6%). Logistic regression analysis showed that suPAR at 24-h post-sepsis diagnosis remained an independent S-AKI risk factor after adjusting for mechanical ventilation, blood urea nitrogen, and pH.Conclusions The findings suggest that plasma suPAR may be a potential biomarker for early S-AKI diagnosis. |
| format | Article |
| id | doaj-art-091fc3462f734875aa13857830f6f2d6 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-091fc3462f734875aa13857830f6f2d62025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2307959Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injuryWenwen Zhang0Yue Gu1Jing Zhou2Juntao Wang3Xiaoru Zhao4Xiaoyu Deng5Han Li6Lei Yan7Xiaojing Jiao8Fengmin Shao9Department of Nephrology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Key Laboratory for Kidney Disease and Immunology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Key Laboratory for Kidney Disease and Immunology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, The First People’s Hospital of Shangqiu, Shangqiu, ChinaDepartment of Nephrology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Henan University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Key Laboratory for Kidney Disease and Immunology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Key Laboratory for Kidney Disease and Immunology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Nephrology, Henan Provincial Clinical Research Center for Kidney Disease, Henan Key Laboratory for Kidney Disease and Immunology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, ChinaBackground Sepsis-associated acute kidney injury (S-AKI) is a critical illness and is often associated with high morbidity and mortality rates. The soluble urokinase-type plasminogen activator receptor (suPAR) is an important immune mediator and is involved in kidney injury. However, its diagnostic value in S-AKI patients remains unclear. Therefore, we assessed the early predictive value of suPAR for S-AKI patients.Methods We prospectively enrolled adult patients, immediately after fulfilling the sepsis-3 criteria. Plasma suPAR levels at 0-, 12-, 24-, and 48-h post-sepsis diagnosis were measured. S-AKI development was the primary outcome. S-AKI risk factors were analyzed using logistic regression, and the value of plasma suPAR for early S-AKI diagnosis was assessed using receiver operating characteristic (ROC) curves.Results Of 179 sepsis patients, 63 (35.2%) developed AKI during hospitalization. At 12-, 24-, and 48-h post-sepsis diagnosis, plasma suPAR levels were significantly higher in patients with S-AKI than in patients without S-AKI (p < 0.05). The plasma suPAR had the highest area under the ROC curve of 0.700 (95% confidence interval (CI), 0.621–0.779) at 24-h post-sepsis diagnosis, at which the best discrimination ability for S-AKI was achieved with suPAR of ≥6.31 ng/mL (sensitivity 61.9% and specificity 71.6%). Logistic regression analysis showed that suPAR at 24-h post-sepsis diagnosis remained an independent S-AKI risk factor after adjusting for mechanical ventilation, blood urea nitrogen, and pH.Conclusions The findings suggest that plasma suPAR may be a potential biomarker for early S-AKI diagnosis.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2307959Acute kidney injuryICUsepsissoluble urokinase-type plasminogen activator receptor |
| spellingShingle | Wenwen Zhang Yue Gu Jing Zhou Juntao Wang Xiaoru Zhao Xiaoyu Deng Han Li Lei Yan Xiaojing Jiao Fengmin Shao Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury Renal Failure Acute kidney injury ICU sepsis soluble urokinase-type plasminogen activator receptor |
| title | Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury |
| title_full | Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury |
| title_fullStr | Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury |
| title_full_unstemmed | Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury |
| title_short | Clinical value of soluble urokinase-type plasminogen activator receptor in predicting sepsis-associated acute kidney injury |
| title_sort | clinical value of soluble urokinase type plasminogen activator receptor in predicting sepsis associated acute kidney injury |
| topic | Acute kidney injury ICU sepsis soluble urokinase-type plasminogen activator receptor |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2307959 |
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