Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults
Purpose: Dobutamine, a sympathomimetic agent, is widely used clinically, influencing cardiac output, heart rate (HR), and blood pressure (BP), which may impact cerebral blood flow (CBF), critical for brain metabolism. However, the effects of dobutamine on CBF and internal carotid artery (ICA) blood...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000164 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206921599123456 |
|---|---|
| author | Fengxia Yu Dong Liu Xia Ma Yawen Liu Linkun Cai Erwei Zhao Zixu Huang Zhe Zhang Tingting Zhang PengGang Qiao Wei Zheng Chunyan Guo Linxue Qian Pengling Ren Zhenchang Wang |
| author_facet | Fengxia Yu Dong Liu Xia Ma Yawen Liu Linkun Cai Erwei Zhao Zixu Huang Zhe Zhang Tingting Zhang PengGang Qiao Wei Zheng Chunyan Guo Linxue Qian Pengling Ren Zhenchang Wang |
| author_sort | Fengxia Yu |
| collection | DOAJ |
| description | Purpose: Dobutamine, a sympathomimetic agent, is widely used clinically, influencing cardiac output, heart rate (HR), and blood pressure (BP), which may impact cerebral blood flow (CBF), critical for brain metabolism. However, the effects of dobutamine on CBF and internal carotid artery (ICA) blood flow remain unclear, with contradictory reported in both clinical and animal studies. It is necessary to investigate the effects of dobutamine on cervical and cerebral hemodynamics. This study aimed to evaluate the effects of dobutamine infusion on ICA blood flow and CBF, explore their relationship, and identify factors influencing CBF to facilitate timely monitoring in clinical practice. Methods: Forty-eight healthy volunteers underwent physiological assessment, ICA ultrasound, and brain magnetic resonance imaging (MRI) data before and after the administration of dobutamine. Paired t and Wilcoxon signed-rank tests were used to analyze changes, while logistic regression explored associations between hemodynamic factors and CBF. Results: Dobutamine infusion significantly increased HR, respiration rate, systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure, while blood oxygen remained stable. Compared with those in the resting state, the peak systolic velocity (Vs), resistance index, pulsatility index, and systolic/diastolic ratio (S/D) increased, whereas end-diastolic velocity (Vd) decreased. ICA diameter and mean velocity showed no significant changes. CBF significantly decreased in the anterior and middle cerebral arteries. Logistic regression identified SBP, DBP, and S/D difference as key factors associated with CBF reduction. Conclusions: Dobutamine altered ICA hemodynamics and reduced CBF in anterior and middle cerebral arteries. Real-time ICA ultrasound monitoring provides valuable guidance during clinical use. |
| format | Article |
| id | doaj-art-091c5fbd65444cd097dd2630ccc72a8b |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-091c5fbd65444cd097dd2630ccc72a8b2025-02-07T04:46:42ZengElsevierBrain Research Bulletin1873-27472025-02-01221111204Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adultsFengxia Yu0Dong Liu1Xia Ma2Yawen Liu3Linkun Cai4Erwei Zhao5Zixu Huang6Zhe Zhang7Tingting Zhang8PengGang Qiao9Wei Zheng10Chunyan Guo11Linxue Qian12Pengling Ren13Zhenchang Wang14Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Precision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaNational Space Science Center, Chinese Academy of Sciences, Beijing 100190, ChinaNational Space Science Center, Chinese Academy of Sciences, Beijing 100190, ChinaChina Astronaut Research and Training Center, Beijing 100086, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaNational Space Science Center, Chinese Academy of Sciences, Beijing 100190, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Correspondence to: No. 95 Yong'an Road, Xicheng District, Beijing, China.Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Precision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Correspondence to: No. 95 Yong'an Road, Xicheng District, Beijing, China.Purpose: Dobutamine, a sympathomimetic agent, is widely used clinically, influencing cardiac output, heart rate (HR), and blood pressure (BP), which may impact cerebral blood flow (CBF), critical for brain metabolism. However, the effects of dobutamine on CBF and internal carotid artery (ICA) blood flow remain unclear, with contradictory reported in both clinical and animal studies. It is necessary to investigate the effects of dobutamine on cervical and cerebral hemodynamics. This study aimed to evaluate the effects of dobutamine infusion on ICA blood flow and CBF, explore their relationship, and identify factors influencing CBF to facilitate timely monitoring in clinical practice. Methods: Forty-eight healthy volunteers underwent physiological assessment, ICA ultrasound, and brain magnetic resonance imaging (MRI) data before and after the administration of dobutamine. Paired t and Wilcoxon signed-rank tests were used to analyze changes, while logistic regression explored associations between hemodynamic factors and CBF. Results: Dobutamine infusion significantly increased HR, respiration rate, systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure, while blood oxygen remained stable. Compared with those in the resting state, the peak systolic velocity (Vs), resistance index, pulsatility index, and systolic/diastolic ratio (S/D) increased, whereas end-diastolic velocity (Vd) decreased. ICA diameter and mean velocity showed no significant changes. CBF significantly decreased in the anterior and middle cerebral arteries. Logistic regression identified SBP, DBP, and S/D difference as key factors associated with CBF reduction. Conclusions: Dobutamine altered ICA hemodynamics and reduced CBF in anterior and middle cerebral arteries. Real-time ICA ultrasound monitoring provides valuable guidance during clinical use.http://www.sciencedirect.com/science/article/pii/S0361923025000164DobutamineArterial spin labelingUltrasoundBrain perfusionCerebral blood flowInternal carotid artery |
| spellingShingle | Fengxia Yu Dong Liu Xia Ma Yawen Liu Linkun Cai Erwei Zhao Zixu Huang Zhe Zhang Tingting Zhang PengGang Qiao Wei Zheng Chunyan Guo Linxue Qian Pengling Ren Zhenchang Wang Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults Brain Research Bulletin Dobutamine Arterial spin labeling Ultrasound Brain perfusion Cerebral blood flow Internal carotid artery |
| title | Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults |
| title_full | Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults |
| title_fullStr | Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults |
| title_full_unstemmed | Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults |
| title_short | Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults |
| title_sort | dobutamine induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults |
| topic | Dobutamine Arterial spin labeling Ultrasound Brain perfusion Cerebral blood flow Internal carotid artery |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000164 |
| work_keys_str_mv | AT fengxiayu dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT dongliu dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT xiama dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT yawenliu dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT linkuncai dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT erweizhao dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT zixuhuang dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT zhezhang dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT tingtingzhang dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT penggangqiao dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT weizheng dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT chunyanguo dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT linxueqian dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT penglingren dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults AT zhenchangwang dobutamineinducedalterationsininternalcarotidarterybloodflowandcerebralbloodflowinhealthyadults |