Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system
Background and purpose:: This study focuses on evaluating a sub-fractionation workflow for intrafraction motion mitigation of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system. Materials and methods:: The investigated workflow consisted of two sub-fractions where int...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Physics and Imaging in Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405631625000119 |
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| author | Georgios Tsekas Cornel Zachiu Gijsbert H. Bol Jochem R.N. van der Voort van Zyp Sandrine M.G. van de Pol Johannes C.J. de Boer Bas W. Raaymakers |
| author_facet | Georgios Tsekas Cornel Zachiu Gijsbert H. Bol Jochem R.N. van der Voort van Zyp Sandrine M.G. van de Pol Johannes C.J. de Boer Bas W. Raaymakers |
| author_sort | Georgios Tsekas |
| collection | DOAJ |
| description | Background and purpose:: This study focuses on evaluating a sub-fractionation workflow for intrafraction motion mitigation of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system. Materials and methods:: The investigated workflow consisted of two sub-fractions where intrafraction drift correction steps were applied based on a daily reference plan. However, the daily contours were only rigidly shifted to match the intrafraction anatomies and therefore the clinical dosimetric constraints might be violated. In this work, daily contours were deformed to match the intrafraction anatomies and the online plans were re-calculated for a total of 15 patients. The deformed prostate contours were inspected by radiation oncologists and corrections were performed when necessary. Finally, a dose-volume parameter evaluation was performed on a sub-fraction level using the clinical plan parameters. Results:: Clinically acceptable coverage was reported for the target structures resulting in mean V95% of 99.7 % and 97.8 % for the clinical target volume (CTV) and planning target volume (PTV) respectively. Sub-fractions with insufficient CTV dose can be explained by the presence of intrafraction rotations and deformations that were not taken into account during intrafraction corrections. Additionally, for no sub-fraction the dose to the organs-at-risk exceeded the clinical constraints. Conclusion:: Given our results on the CTV coverage we can conclude that the sub-fractionation workflow met the dosimetric constraints for the hypofractionated treatment of the analyzed group of prostate cancer patients. A future dose accumulation study can provide further insights into the suitability of the clinical margins. |
| format | Article |
| id | doaj-art-091353715c14409c8763c3a4b448a067 |
| institution | Kabale University |
| issn | 2405-6316 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj-art-091353715c14409c8763c3a4b448a0672025-02-10T04:34:35ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162025-01-0133100706Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy systemGeorgios Tsekas0Cornel Zachiu1Gijsbert H. Bol2Jochem R.N. van der Voort van Zyp3Sandrine M.G. van de Pol4Johannes C.J. de Boer5Bas W. Raaymakers6Corresponding author.; Departement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsDepartement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsDepartement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsDepartement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsDepartement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsDepartement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsDepartement of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The NetherlandsBackground and purpose:: This study focuses on evaluating a sub-fractionation workflow for intrafraction motion mitigation of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system. Materials and methods:: The investigated workflow consisted of two sub-fractions where intrafraction drift correction steps were applied based on a daily reference plan. However, the daily contours were only rigidly shifted to match the intrafraction anatomies and therefore the clinical dosimetric constraints might be violated. In this work, daily contours were deformed to match the intrafraction anatomies and the online plans were re-calculated for a total of 15 patients. The deformed prostate contours were inspected by radiation oncologists and corrections were performed when necessary. Finally, a dose-volume parameter evaluation was performed on a sub-fraction level using the clinical plan parameters. Results:: Clinically acceptable coverage was reported for the target structures resulting in mean V95% of 99.7 % and 97.8 % for the clinical target volume (CTV) and planning target volume (PTV) respectively. Sub-fractions with insufficient CTV dose can be explained by the presence of intrafraction rotations and deformations that were not taken into account during intrafraction corrections. Additionally, for no sub-fraction the dose to the organs-at-risk exceeded the clinical constraints. Conclusion:: Given our results on the CTV coverage we can conclude that the sub-fractionation workflow met the dosimetric constraints for the hypofractionated treatment of the analyzed group of prostate cancer patients. A future dose accumulation study can provide further insights into the suitability of the clinical margins.http://www.sciencedirect.com/science/article/pii/S2405631625000119Prostate cancerMR-linacAdaptive radiotherapyAdapt-to-positionAdapt-to-shapeIntrafraction motion |
| spellingShingle | Georgios Tsekas Cornel Zachiu Gijsbert H. Bol Jochem R.N. van der Voort van Zyp Sandrine M.G. van de Pol Johannes C.J. de Boer Bas W. Raaymakers Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system Physics and Imaging in Radiation Oncology Prostate cancer MR-linac Adaptive radiotherapy Adapt-to-position Adapt-to-shape Intrafraction motion |
| title | Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system |
| title_full | Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system |
| title_fullStr | Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system |
| title_full_unstemmed | Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system |
| title_short | Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system |
| title_sort | dose volume parameter evaluation of a sub fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1 5 t magnetic resonance imaging radiotherapy system |
| topic | Prostate cancer MR-linac Adaptive radiotherapy Adapt-to-position Adapt-to-shape Intrafraction motion |
| url | http://www.sciencedirect.com/science/article/pii/S2405631625000119 |
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