Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD
Objective. To optimize the preparation formula and technology of Chuilian Jianpi granules. Methods. The formulation and preparation process were optimized by single factor experiment and response surface analysis, with the molding rate, hygroscopicity, and fluidity of particles as the comprehensive...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Complexity |
| Online Access: | http://dx.doi.org/10.1155/2021/9992022 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561472493846528 |
|---|---|
| author | Guangjiao Zhou Xiao-Wei Li Jin-Cai Li Xue-Hua Feng |
| author_facet | Guangjiao Zhou Xiao-Wei Li Jin-Cai Li Xue-Hua Feng |
| author_sort | Guangjiao Zhou |
| collection | DOAJ |
| description | Objective. To optimize the preparation formula and technology of Chuilian Jianpi granules. Methods. The formulation and preparation process were optimized by single factor experiment and response surface analysis, with the molding rate, hygroscopicity, and fluidity of particles as the comprehensive evaluation indexes, and the comprehensive score as the response value according to different weights. To further evaluate the stability and feasibility of the preparation formulation and technology, the physical fingerprint of the granules was constructed by seven indicators including particle tap density, bulk density, hygroscopicity, water content, angle of repose, Hausner ratio, and relative homogeneity index. Results. The optimum formula conditions of Chuilian Jianpi granules were as follows: the dosage ratio of drug to adjuvant was 1 : 0.8, lactose:mannitol = 1.5 : 1, and the amount of wetting agent (90% ethanol) was 25% of the granules, with high-speed stirring granulation. The similarity of the physical fingerprints of the 10 batches of Chuilian Jianpi granules was high, which is above 98.5%. Conclusion. The optimized preparation technology was stable and feasible, which can provide reference for the development of Chuilian Jianpi granules and other Chinese medicine granules. |
| format | Article |
| id | doaj-art-09132ea732344dbea50cb5be8d4a639d |
| institution | Kabale University |
| issn | 1076-2787 1099-0526 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Complexity |
| spelling | doaj-art-09132ea732344dbea50cb5be8d4a639d2025-02-03T01:24:53ZengWileyComplexity1076-27871099-05262021-01-01202110.1155/2021/99920229992022Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbDGuangjiao Zhou0Xiao-Wei Li1Jin-Cai Li2Xue-Hua Feng3Bozhou Chinese Medicine Institute, Anhui Academy of Chinese Medicine, Bozhou 236800, ChinaMeng Cheng Hospital of Chinese Medicine, Bozhou 236800, ChinaBozhou Chinese Medicine Institute, Anhui Academy of Chinese Medicine, Bozhou 236800, ChinaAnhui Xinhua University, Hefei 230088, ChinaObjective. To optimize the preparation formula and technology of Chuilian Jianpi granules. Methods. The formulation and preparation process were optimized by single factor experiment and response surface analysis, with the molding rate, hygroscopicity, and fluidity of particles as the comprehensive evaluation indexes, and the comprehensive score as the response value according to different weights. To further evaluate the stability and feasibility of the preparation formulation and technology, the physical fingerprint of the granules was constructed by seven indicators including particle tap density, bulk density, hygroscopicity, water content, angle of repose, Hausner ratio, and relative homogeneity index. Results. The optimum formula conditions of Chuilian Jianpi granules were as follows: the dosage ratio of drug to adjuvant was 1 : 0.8, lactose:mannitol = 1.5 : 1, and the amount of wetting agent (90% ethanol) was 25% of the granules, with high-speed stirring granulation. The similarity of the physical fingerprints of the 10 batches of Chuilian Jianpi granules was high, which is above 98.5%. Conclusion. The optimized preparation technology was stable and feasible, which can provide reference for the development of Chuilian Jianpi granules and other Chinese medicine granules.http://dx.doi.org/10.1155/2021/9992022 |
| spellingShingle | Guangjiao Zhou Xiao-Wei Li Jin-Cai Li Xue-Hua Feng Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD Complexity |
| title | Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD |
| title_full | Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD |
| title_fullStr | Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD |
| title_full_unstemmed | Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD |
| title_short | Study on Preparation Technology and Physical Fingerprint of Chuilian Jianpi Granules Based on QbD |
| title_sort | study on preparation technology and physical fingerprint of chuilian jianpi granules based on qbd |
| url | http://dx.doi.org/10.1155/2021/9992022 |
| work_keys_str_mv | AT guangjiaozhou studyonpreparationtechnologyandphysicalfingerprintofchuilianjianpigranulesbasedonqbd AT xiaoweili studyonpreparationtechnologyandphysicalfingerprintofchuilianjianpigranulesbasedonqbd AT jincaili studyonpreparationtechnologyandphysicalfingerprintofchuilianjianpigranulesbasedonqbd AT xuehuafeng studyonpreparationtechnologyandphysicalfingerprintofchuilianjianpigranulesbasedonqbd |