Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature
Background. Steroid cell ovarian tumors, not otherwise specified, represent a unique cause of female virilization. Most commonly encountered in premenopausal women, these tumors can exist throughout a women’s lifetime, from before puberty until after menopause. Case. Steroid cell, not otherwise spec...
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Wiley
2012-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2012/253152 |
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| author | Paul Singh Frank Deleon Ralph Anderson |
| author_facet | Paul Singh Frank Deleon Ralph Anderson |
| author_sort | Paul Singh |
| collection | DOAJ |
| description | Background. Steroid cell ovarian tumors, not otherwise specified, represent a unique cause of female virilization. Most commonly encountered in premenopausal women, these tumors can exist throughout a women’s lifetime, from before puberty until after menopause. Case. Steroid cell, not otherwise specified, was diagnosed in a 70-year-old female significant for hirsutism. The patient demonstrated elevated total testosterone levels with normal gonadotropins, DHEA, and DHEA-S levels. CT imaging revealed a right ovarian mass and subsequent laparoscopic right oophorectomy yielded clinical improvement promptly. Conclusion. Virilization in females can occur based on ovarian or adrenal pathology. In terms of ovarian-based female virilization, many tumors exist that may induce women to demonstrate masculine features, such as pure Sertoli, pure Leydig, Sertoli-Leydig combinations, and gynandroblastomas. Each of these tumor types possesses a unique histologic pattern that allows for pathologic identification after removal. A rare source of ovarian-based female virilization is steroid cell neoplasms, not otherwise specified, that do not demonstrate these specific histologic characteristics and thus represent a diagnosis of exclusion after other causes of ovarian-based female virilization have been ruled out. |
| format | Article |
| id | doaj-art-090fc110b1cf41f6ae620f5ab28ce283 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-090fc110b1cf41f6ae620f5ab28ce2832025-08-20T03:55:29ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922012-01-01201210.1155/2012/253152253152Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the LiteraturePaul Singh0Frank Deleon1Ralph Anderson2Department of Obstetrics and Gynecology, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USADivision of Reproductive Medicine, Department of Obstetrics and Gynecology, John Peter Smith Hospital, Fort Worth, TX 76104, USADivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, John Peter Smith Hospital, Fort Worth, TX 76104, USABackground. Steroid cell ovarian tumors, not otherwise specified, represent a unique cause of female virilization. Most commonly encountered in premenopausal women, these tumors can exist throughout a women’s lifetime, from before puberty until after menopause. Case. Steroid cell, not otherwise specified, was diagnosed in a 70-year-old female significant for hirsutism. The patient demonstrated elevated total testosterone levels with normal gonadotropins, DHEA, and DHEA-S levels. CT imaging revealed a right ovarian mass and subsequent laparoscopic right oophorectomy yielded clinical improvement promptly. Conclusion. Virilization in females can occur based on ovarian or adrenal pathology. In terms of ovarian-based female virilization, many tumors exist that may induce women to demonstrate masculine features, such as pure Sertoli, pure Leydig, Sertoli-Leydig combinations, and gynandroblastomas. Each of these tumor types possesses a unique histologic pattern that allows for pathologic identification after removal. A rare source of ovarian-based female virilization is steroid cell neoplasms, not otherwise specified, that do not demonstrate these specific histologic characteristics and thus represent a diagnosis of exclusion after other causes of ovarian-based female virilization have been ruled out.http://dx.doi.org/10.1155/2012/253152 |
| spellingShingle | Paul Singh Frank Deleon Ralph Anderson Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature Case Reports in Obstetrics and Gynecology |
| title | Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature |
| title_full | Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature |
| title_fullStr | Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature |
| title_full_unstemmed | Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature |
| title_short | Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature |
| title_sort | steroid cell ovarian neoplasm not otherwise specified a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2012/253152 |
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