HISTOPATHOLOGICAL STUDY OF SEPSIS EXPERIMENTALLY INDUCED BY CECAL LIGATION AND PUNCTURE IN RATS
The aim of this study was to investigate the histopathological lesions in the liver,kidney and lung sections in rats with sepsis that experimentally induced by cecal ligation and puncture CLP procedure to induce intra-abdominal infection. It was found that CLP models leads to higher mortality rate c...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
College of Veterinary Medicine, University of Basrah, Iraq
2013-06-01
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| Series: | Basrah Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://bjvr.uobasrah.edu.iq/article_76193_9470f07d173347c08c1bc82ed15f925c.pdf |
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| Summary: | The aim of this study was to investigate the histopathological lesions in the
liver,kidney and lung sections in rats with sepsis that experimentally induced by cecal
ligation and puncture CLP procedure to induce intra-abdominal infection. It was found
that CLP models leads to higher mortality rate comparisons to sham-operated and un–
operated animals. Also there were severe lesions in the liver , kidney and lung of rats
with sepsis , characterized by severe massive necrosis in hepatic cells , while the
histopathological changes in kidney of CLP rats revealed severe glomerulonehritis with
infiltration of inflammatory cells , in lung , severe interstitial and bronchial pneumonia ,
with presence of severe thickening of blood vessel wall with thrombi . In conclusion, the
results of this study have demonstrated that CLP induces high mortality rate , an acute
systemic septic state with multiple organ dysfunction especially the Liver , kidney and
Lung based on histopathological observations . These features were not observed in sham
- operated or un-operated rats . |
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| ISSN: | 1813-8497 2410-8456 |